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Micro-Engineered Devices for Point-of-Care Blood Clot Retraction Testing

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개인저자Li, Zida.
단체저자명University of Michigan. Mechanical Engineering.
서명/저자사항Micro-Engineered Devices for Point-of-Care Blood Clot Retraction Testing.
발행사항[S.l.] : University of Michigan., 2018
발행사항Ann Arbor : ProQuest Dissertations & Theses, 2018
형태사항108 p.
소장본 주기School code: 0127.
ISBN9780438126442
일반주기 Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
Adviser: Jianping Fu.
요약Blood coagulation is a critical hemostatic process that must be properly regulated to maintain the delicate balance between bleeding and clotting. Disorders of blood coagulation can expose patients to the risk of either bleeding disorders or thr
요약This thesis aims to leverage advances in micro-technology and functional soft materials to develop miniaturized devices for clot retraction force measurements, providing accurate and reliable blood coagulation assays with potentials for point-of
요약First, I designed a force-sensing device, named Miniaturized Hemoretractometer (mHRM), based on image acquisition and analysis to measure contraction force generated during blood clotting. This clot retraction force served as an indicator of coa
요약Acquiring electrical signals instead of images could vastly simplify the instrumentation of mHRM. However, integrating conductive materials into soft elastomer (PDMS) was a challenge. To address this problem, I developed a method to coat carbon
요약Finally, I applied this CNT deposition method into the design of mHRM and developed a CNT strain sensor based mHRM (CNT-mHRM). I investigated the parameters that affected the sensitivity of CNT-mHRM devices and demonstrated that CNT-mHRM generat
일반주제명Mechanical engineering.
언어영어
기본자료 저록Dissertation Abstracts International79-12B(E).
Dissertation Abstract International
대출바로가기http://www.riss.kr/pdu/ddodLink.do?id=T15000538

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