| LDR | | 00000nmm u2200205 4500 |
| 001 | | 000000330853 |
| 005 | | 20241105133303 |
| 008 | | 181129s2018 ||| | | | eng d |
| 020 | |
▼a 9780438126442 |
| 035 | |
▼a (MiAaPQ)AAI10903038 |
| 035 | |
▼a (MiAaPQ)umichrackham:001100 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 049 | 1 |
▼f DP |
| 082 | 0 |
▼a 621 |
| 100 | 1 |
▼a Li, Zida. |
| 245 | 10 |
▼a Micro-Engineered Devices for Point-of-Care Blood Clot Retraction Testing. |
| 260 | |
▼a [S.l.] :
▼b University of Michigan.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 108 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B. |
| 500 | |
▼a Adviser: Jianping Fu. |
| 502 | 1 |
▼a Thesis (Ph.D.)--University of Michigan, 2018. |
| 520 | |
▼a Blood coagulation is a critical hemostatic process that must be properly regulated to maintain the delicate balance between bleeding and clotting. Disorders of blood coagulation can expose patients to the risk of either bleeding disorders or thr |
| 520 | |
▼a This thesis aims to leverage advances in micro-technology and functional soft materials to develop miniaturized devices for clot retraction force measurements, providing accurate and reliable blood coagulation assays with potentials for point-of |
| 520 | |
▼a First, I designed a force-sensing device, named Miniaturized Hemoretractometer (mHRM), based on image acquisition and analysis to measure contraction force generated during blood clotting. This clot retraction force served as an indicator of coa |
| 520 | |
▼a Acquiring electrical signals instead of images could vastly simplify the instrumentation of mHRM. However, integrating conductive materials into soft elastomer (PDMS) was a challenge. To address this problem, I developed a method to coat carbon |
| 520 | |
▼a Finally, I applied this CNT deposition method into the design of mHRM and developed a CNT strain sensor based mHRM (CNT-mHRM). I investigated the parameters that affected the sensitivity of CNT-mHRM devices and demonstrated that CNT-mHRM generat |
| 590 | |
▼a School code: 0127. |
| 650 | 4 |
▼a Mechanical engineering. |
| 690 | |
▼a 0548 |
| 710 | 20 |
▼a University of Michigan.
▼b Mechanical Engineering. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-12B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0127 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T15000538
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자
▼b 관리자 |