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Topological Properties of Eukaryotic Gene Regulatory Networks

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개인저자Ouma, Zachary Wilberforce.
단체저자명The Ohio State University. Molecular, Cellular and Developmental Biology.
서명/저자사항Topological Properties of Eukaryotic Gene Regulatory Networks.
발행사항[S.l.] : The Ohio State University., 2017
발행사항Ann Arbor : ProQuest Dissertations & Theses, 2017
형태사항178 p.
소장본 주기School code: 0168.
ISBN9780438098848
일반주기 Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
Adviser: Richard Slotkin.
요약Understanding transcriptional regulation of gene expression on a genome-wide scale is predicated on deciphering interactions between all participating regulatory proteins and DNA. Advances in genomics are facilitating the high-throughput identif
요약In this work, I first present an investigative inquiry whose goal was to identify the source of unaligned sequence reads generated in studies aimed at identifying transcription factor binding sites (TFBSs). Determining TFBSs and the resulting ar
요약Secondly, I describe the architectural organization and associated emergent topological properties of GRNs that describe protein-DNA interactions (PDIs) in several model eukaryotes. By analyzing GRN connectivity, results presented here show that
요약Lastly, I discuss future perspectives of this work. I briefly present models that can be used to capture GRN dynamics. I focus on a class of logical models---the Boolean network model, and propose a framework for constructing and implementing a
일반주제명Molecular biology.
Bioinformatics.
Developmental biology.
언어영어
기본자료 저록Dissertation Abstracts International79-12B(E).
Dissertation Abstract International
대출바로가기http://www.riss.kr/pdu/ddodLink.do?id=T15000337

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