| LDR | | 02423nmm uu200457 4500 |
| 001 | | 000000330695 |
| 005 | | 20240805161953 |
| 008 | | 181129s2017 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438098848 |
| 035 | |
▼a (MiAaPQ)AAI10901946 |
| 035 | |
▼a (MiAaPQ)OhioLINK:osu1512041623395438 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 574 |
| 100 | 1 |
▼a Ouma, Zachary Wilberforce. |
| 245 | 10 |
▼a Topological Properties of Eukaryotic Gene Regulatory Networks. |
| 260 | |
▼a [S.l.] :
▼b The Ohio State University.,
▼c 2017 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2017 |
| 300 | |
▼a 178 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B. |
| 500 | |
▼a Adviser: Richard Slotkin. |
| 502 | 1 |
▼a Thesis (Ph.D.)--The Ohio State University, 2017. |
| 520 | |
▼a Understanding transcriptional regulation of gene expression on a genome-wide scale is predicated on deciphering interactions between all participating regulatory proteins and DNA. Advances in genomics are facilitating the high-throughput identif |
| 520 | |
▼a In this work, I first present an investigative inquiry whose goal was to identify the source of unaligned sequence reads generated in studies aimed at identifying transcription factor binding sites (TFBSs). Determining TFBSs and the resulting ar |
| 520 | |
▼a Secondly, I describe the architectural organization and associated emergent topological properties of GRNs that describe protein-DNA interactions (PDIs) in several model eukaryotes. By analyzing GRN connectivity, results presented here show that |
| 520 | |
▼a Lastly, I discuss future perspectives of this work. I briefly present models that can be used to capture GRN dynamics. I focus on a class of logical models---the Boolean network model, and propose a framework for constructing and implementing a |
| 590 | |
▼a School code: 0168. |
| 650 | 4 |
▼a Molecular biology. |
| 650 | 4 |
▼a Bioinformatics. |
| 650 | 4 |
▼a Developmental biology. |
| 690 | |
▼a 0307 |
| 690 | |
▼a 0715 |
| 690 | |
▼a 0758 |
| 710 | 20 |
▼a The Ohio State University.
▼b Molecular, Cellular and Developmental Biology. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-12B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0168 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2017 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T15000337
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |