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Factors Influencing Percutaneous Absorption: Effects of Solvents, Solute Physicochemical Properties, and Penetration Enhancer

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개인저자Intarakumhaeng, Rattikorn.
단체저자명University of Cincinnati. Pharmacy: Pharmaceutical Sciences/Biopharmaceutics.
서명/저자사항Factors Influencing Percutaneous Absorption: Effects of Solvents, Solute Physicochemical Properties, and Penetration Enhancer.
발행사항[S.l.] : University of Cincinnati., 2017
발행사항Ann Arbor : ProQuest Dissertations & Theses, 2017
형태사항197 p.
소장본 주기School code: 0045.
ISBN9780438091061
일반주기 Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B.
요약Skin has been the focus of research as a site of local and systemic drug delivery due to its advantages over other routes of drug delivery. However, the determining factors that could affect the transport of compounds through and into the skin a
요약The objective of Chapter 3 was to examine the effects of solvents upon the deposition of a model solute, corticosterone (CS) in the stratum corneum (SC) that could influence skin absorption of the solute after topical application. The solvents u
요약The study performed in Chapter 4 was a continuing effort to investigate the effects of solvents on skin absorption of lipophilic and polar solutes and examine the relationships between solute physicochemical properties and skin absorption of the
요약In Chapter 5, we probed the mechanism of the observed high finite dose skin permeation of urea, in contrast to its permeability coefficient. A small hydrophilic solute ethylene glycol (EG) with molecular weight similar to urea was studied for co
요약Chapter 6 aimed to examine the skin penetration of petrolatum and soybean oil after skin application with and without a penetration enhancer, glyceryl monooleate (GlyMOle). GlyMOle was found to enhance the penetration of petrolatum into the spli
일반주제명Pharmaceutical sciences.
언어영어
기본자료 저록Dissertation Abstracts International79-10B(E).
Dissertation Abstract International
대출바로가기http://www.riss.kr/pdu/ddodLink.do?id=T15000199

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