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020 ▼a 9780438091061
035 ▼a (MiAaPQ)AAI10871326
035 ▼a (MiAaPQ)OhioLINK:ucin1491316295006087
040 ▼a MiAaPQ ▼c MiAaPQ ▼d 248032
0820 ▼a 615
1001 ▼a Intarakumhaeng, Rattikorn.
24510 ▼a Factors Influencing Percutaneous Absorption: Effects of Solvents, Solute Physicochemical Properties, and Penetration Enhancer.
260 ▼a [S.l.] : ▼b University of Cincinnati., ▼c 2017
260 1 ▼a Ann Arbor : ▼b ProQuest Dissertations & Theses, ▼c 2017
300 ▼a 197 p.
500 ▼a Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B.
5021 ▼a Thesis (Ph.D.)--University of Cincinnati, 2017.
520 ▼a Skin has been the focus of research as a site of local and systemic drug delivery due to its advantages over other routes of drug delivery. However, the determining factors that could affect the transport of compounds through and into the skin a
520 ▼a The objective of Chapter 3 was to examine the effects of solvents upon the deposition of a model solute, corticosterone (CS) in the stratum corneum (SC) that could influence skin absorption of the solute after topical application. The solvents u
520 ▼a The study performed in Chapter 4 was a continuing effort to investigate the effects of solvents on skin absorption of lipophilic and polar solutes and examine the relationships between solute physicochemical properties and skin absorption of the
520 ▼a In Chapter 5, we probed the mechanism of the observed high finite dose skin permeation of urea, in contrast to its permeability coefficient. A small hydrophilic solute ethylene glycol (EG) with molecular weight similar to urea was studied for co
520 ▼a Chapter 6 aimed to examine the skin penetration of petrolatum and soybean oil after skin application with and without a penetration enhancer, glyceryl monooleate (GlyMOle). GlyMOle was found to enhance the penetration of petrolatum into the spli
590 ▼a School code: 0045.
650 4 ▼a Pharmaceutical sciences.
690 ▼a 0572
71020 ▼a University of Cincinnati. ▼b Pharmacy: Pharmaceutical Sciences/Biopharmaceutics.
7730 ▼t Dissertation Abstracts International ▼g 79-10B(E).
773 ▼t Dissertation Abstract International
790 ▼a 0045
791 ▼a Ph.D.
792 ▼a 2017
793 ▼a English
85640 ▼u http://www.riss.kr/pdu/ddodLink.do?id=T15000199 ▼n KERIS
980 ▼a 201812 ▼f 2019
990 ▼a 관리자