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Small-molecule TLR8 Antagonists via Structure-based Rational Design
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| 자료유형 | E-Book |
|---|---|
| 개인저자 | Hu, Zhenyi. |
| 단체저자명 | University of Colorado at Boulder. Chemistry. |
| 서명/저자사항 | Small-molecule TLR8 Antagonists via Structure-based Rational Design. |
| 발행사항 | [S.l.] : University of Colorado at Boulder., 2018 |
| 발행사항 | Ann Arbor : ProQuest Dissertations & Theses, 2018 |
| 형태사항 | 262 p. |
| 소장본 주기 | School code: 0051. |
| ISBN | 9780438384057 |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 80-02(E), Section: B.
Adviser: Hang Yin. |
| 요약 | Immune system plays a critical role in defense against various virus and bacteria, and it's composed of innate immune system and adaptive immune system. Innate immune system is vital for immune response because of its prompt responses to a varie |
| 요약 | Among pattern recognition receptors, Toll-like receptors (TLRs) are the most well studied ones. Toll-like receptors (TLRs) play a key role in the innate immune system by recognizing structurally conserved PAMP and DAMP. The goal of this doctoral |
| 요약 | Chapter 1 focus on introduction of immune system including innate immune system and adaptive immune system. Pattern recognition receptors are then introduced, and Toll-like receptors are specially focused on. |
| 요약 | Chapter 2 describes the design and development of TLR8 antagonist utilizing structure-based rational design. And Structure--Activity Relationship (SAR) study of TLR8 antagonists is introduced in chapter 3. |
| 요약 | Chapter 4 describes the mechanism of TLR8 inhibition induced by CU-CPT antagonists. Chapter 5 introduces biological validation of CU-CPT antagonists, showing high potency and selectivity of these compounds, which indicates the therapeutic potent |
| 일반주제명 | Chemistry. Organic chemistry. Molecular chemistry. |
| 언어 | 영어 |
| 기본자료 저록 | Dissertation Abstracts International80-02B(E). Dissertation Abstract International |
| 대출바로가기 | http://www.riss.kr/pdu/ddodLink.do?id=T15000113 |
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인쇄
| No. | 등록번호 | 청구기호 | 소장처 | 도서상태 | 반납예정일 | 예약 | 서비스 | 매체정보 |
|---|---|---|---|---|---|---|---|---|
| 1 | WE00024848 | 540 | 가야대학교// | 대출가능 |
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