| LDR | | 00000nmm u2200205 4500 |
| 001 | | 000000330521 |
| 005 | | 20241101095845 |
| 008 | | 181129s2018 ||| | | | eng d |
| 020 | |
▼a 9780438384057 |
| 035 | |
▼a (MiAaPQ)AAI10846134 |
| 035 | |
▼a (MiAaPQ)colorado:15647 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 049 | 1 |
▼f DP |
| 082 | 0 |
▼a 540 |
| 100 | 1 |
▼a Hu, Zhenyi. |
| 245 | 10 |
▼a Small-molecule TLR8 Antagonists via Structure-based Rational Design. |
| 260 | |
▼a [S.l.] :
▼b University of Colorado at Boulder.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 262 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 80-02(E), Section: B. |
| 500 | |
▼a Adviser: Hang Yin. |
| 502 | 1 |
▼a Thesis (Ph.D.)--University of Colorado at Boulder, 2018. |
| 520 | |
▼a Immune system plays a critical role in defense against various virus and bacteria, and it's composed of innate immune system and adaptive immune system. Innate immune system is vital for immune response because of its prompt responses to a varie |
| 520 | |
▼a Among pattern recognition receptors, Toll-like receptors (TLRs) are the most well studied ones. Toll-like receptors (TLRs) play a key role in the innate immune system by recognizing structurally conserved PAMP and DAMP. The goal of this doctoral |
| 520 | |
▼a Chapter 1 focus on introduction of immune system including innate immune system and adaptive immune system. Pattern recognition receptors are then introduced, and Toll-like receptors are specially focused on. |
| 520 | |
▼a Chapter 2 describes the design and development of TLR8 antagonist utilizing structure-based rational design. And Structure--Activity Relationship (SAR) study of TLR8 antagonists is introduced in chapter 3. |
| 520 | |
▼a Chapter 4 describes the mechanism of TLR8 inhibition induced by CU-CPT antagonists. Chapter 5 introduces biological validation of CU-CPT antagonists, showing high potency and selectivity of these compounds, which indicates the therapeutic potent |
| 590 | |
▼a School code: 0051. |
| 650 | 4 |
▼a Chemistry. |
| 650 | 4 |
▼a Organic chemistry. |
| 650 | 4 |
▼a Molecular chemistry. |
| 690 | |
▼a 0485 |
| 690 | |
▼a 0490 |
| 690 | |
▼a 0431 |
| 710 | 20 |
▼a University of Colorado at Boulder.
▼b Chemistry. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 80-02B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0051 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T15000113
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자
▼b 관리자 |