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The Human Antibody Response to DENV2 Infection and Vaccination

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자료유형E-Book
개인저자Gallichotte, Emily Newman.
단체저자명The University of North Carolina at Chapel Hill. Microbiology and Immunology.
서명/저자사항The Human Antibody Response to DENV2 Infection and Vaccination.
발행사항[S.l.] : The University of North Carolina at Chapel Hill., 2018
발행사항Ann Arbor : ProQuest Dissertations & Theses, 2018
형태사항154 p.
소장본 주기School code: 0153.
ISBN9780438349414
일반주기 Source: Dissertation Abstracts International, Volume: 80-01(E), Section: B.
Advisers: Aravinda de Silva
요약Dengue viruses (DENVs) are mosquito-borne flaviviruses that are estimated to infect 390 million people each year. Dengue is a major global public health concern because people infected with the virus can develop dengue fever or severe dengue hem
요약There are four antigenically distinct DENV serotypes, named DENV1 through DENV4. For my studies, I focused on DENV2 as a model to understand human protective immunity following infection or vaccination. Following natural DENV2 infections, indivi
요약I sought to determine if DENV vaccination is able to elicit the same types of DENV2 antibodies implicated in protective immunity following natural infections. I observed that two different live DENV vaccines were able to elicit antibodies target
요약Investigators studying DENV pathogenesis and vaccines had previously focused on the functional properties (neutralization) of human antibodies, with little consideration of the actual epitopes and mechanisms of protective immunity. Recent result
일반주제명Virology.
Immunology.
언어영어
기본자료 저록Dissertation Abstracts International80-01B(E).
Dissertation Abstract International
대출바로가기http://www.riss.kr/pdu/ddodLink.do?id=T14999860

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