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020 ▼a 9780438349414
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035 ▼a (MiAaPQ)unc:18061
040 ▼a MiAaPQ ▼c MiAaPQ ▼d 248032
0491 ▼f DP
0820 ▼a 576.6
1001 ▼a Gallichotte, Emily Newman.
24514 ▼a The Human Antibody Response to DENV2 Infection and Vaccination.
260 ▼a [S.l.] : ▼b The University of North Carolina at Chapel Hill., ▼c 2018
260 1 ▼a Ann Arbor : ▼b ProQuest Dissertations & Theses, ▼c 2018
300 ▼a 154 p.
500 ▼a Source: Dissertation Abstracts International, Volume: 80-01(E), Section: B.
500 ▼a Advisers: Aravinda de Silva
5021 ▼a Thesis (Ph.D.)--The University of North Carolina at Chapel Hill, 2018.
520 ▼a Dengue viruses (DENVs) are mosquito-borne flaviviruses that are estimated to infect 390 million people each year. Dengue is a major global public health concern because people infected with the virus can develop dengue fever or severe dengue hem
520 ▼a There are four antigenically distinct DENV serotypes, named DENV1 through DENV4. For my studies, I focused on DENV2 as a model to understand human protective immunity following infection or vaccination. Following natural DENV2 infections, indivi
520 ▼a I sought to determine if DENV vaccination is able to elicit the same types of DENV2 antibodies implicated in protective immunity following natural infections. I observed that two different live DENV vaccines were able to elicit antibodies target
520 ▼a Investigators studying DENV pathogenesis and vaccines had previously focused on the functional properties (neutralization) of human antibodies, with little consideration of the actual epitopes and mechanisms of protective immunity. Recent result
590 ▼a School code: 0153.
650 4 ▼a Virology.
650 4 ▼a Immunology.
690 ▼a 0720
690 ▼a 0982
71020 ▼a The University of North Carolina at Chapel Hill. ▼b Microbiology and Immunology.
7730 ▼t Dissertation Abstracts International ▼g 80-01B(E).
773 ▼t Dissertation Abstract International
790 ▼a 0153
791 ▼a Ph.D.
792 ▼a 2018
793 ▼a English
85640 ▼u http://www.riss.kr/pdu/ddodLink.do?id=T14999860 ▼n KERIS
980 ▼a 201812 ▼f 2019
990 ▼a 관리자 ▼b 관리자