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Survival Motor Neuron Protein Interaction Partners in Drosophila melanogaster
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| 자료유형 | E-Book |
|---|---|
| 개인저자 | Gray, Kelsey Marie. |
| 단체저자명 | The University of North Carolina at Chapel Hill. Genetics and Molecular Biology. |
| 서명/저자사항 | Survival Motor Neuron Protein Interaction Partners in Drosophila melanogaster. |
| 발행사항 | [S.l.] : The University of North Carolina at Chapel Hill., 2018 |
| 발행사항 | Ann Arbor : ProQuest Dissertations & Theses, 2018 |
| 형태사항 | 139 p. |
| 소장본 주기 | School code: 0153. |
| ISBN | 9780438033368 |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B.
Advisers: Arnold G. Matera |
| 요약 | Spinal Muscular Atrophy (SMA) is a neuromuscular disorder that results from biallelic loss-of-function mutations in the human survival motor neuron 1 (SMN1) gene. Tissue-specific and housekeeping functions have been ascribed to SMN |
| 요약 | We also identified Slmb, SkpA, and Cullin 1 as being highly enriched in Flag-SMN samples as compared to the control sample. Together, these proteins comprise the SCFSlmb E3 ubiquitin ligase. These interactions were verified in Drosophila S2 cell |
| 요약 | We identified additional protein interactions of SMN with CG2941, nucleosome assembly protein 1 (Nap1), and Bendless (Ben). Each of these interactions was verified in cell culture or using antibodies generated specifically for the protein of int |
| 요약 | We have examined SMN protein interactions in the context of developing Drosophila melanogaster embryos, with follow-up studies in mouse, and human systems. When SMN is unable to self-oligomerize, the Slmb degron is highly accessible, and thus S |
| 일반주제명 | Molecular biology. Genetics. |
| 언어 | 영어 |
| 기본자료 저록 | Dissertation Abstracts International79-10B(E). Dissertation Abstract International |
| 대출바로가기 | http://www.riss.kr/pdu/ddodLink.do?id=T14996834 |
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| No. | 등록번호 | 청구기호 | 소장처 | 도서상태 | 반납예정일 | 예약 | 서비스 | 매체정보 |
|---|---|---|---|---|---|---|---|---|
| 1 | WE00024410 | 574 | 가야대학교// | 대출가능 |
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