| LDR | | 00000nmm u2200205 4500 |
| 001 | | 000000330083 |
| 005 | | 20241023134311 |
| 008 | | 181129s2018 ||| | | | eng d |
| 020 | |
▼a 9780438033368 |
| 035 | |
▼a (MiAaPQ)AAI10744561 |
| 035 | |
▼a (MiAaPQ)unc:17501 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 049 | 1 |
▼f DP |
| 082 | 0 |
▼a 574 |
| 100 | 1 |
▼a Gray, Kelsey Marie. |
| 245 | 10 |
▼a Survival Motor Neuron Protein Interaction Partners in Drosophila melanogaster. |
| 260 | |
▼a [S.l.] :
▼b The University of North Carolina at Chapel Hill.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 139 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B. |
| 500 | |
▼a Advisers: Arnold G. Matera |
| 502 | 1 |
▼a Thesis (Ph.D.)--The University of North Carolina at Chapel Hill, 2018. |
| 520 | |
▼a Spinal Muscular Atrophy (SMA) is a neuromuscular disorder that results from biallelic loss-of-function mutations in the human survival motor neuron 1 (SMN1) gene. Tissue-specific and housekeeping functions have been ascribed to SMN |
| 520 | |
▼a We also identified Slmb, SkpA, and Cullin 1 as being highly enriched in Flag-SMN samples as compared to the control sample. Together, these proteins comprise the SCFSlmb E3 ubiquitin ligase. These interactions were verified in Drosophila S2 cell |
| 520 | |
▼a We identified additional protein interactions of SMN with CG2941, nucleosome assembly protein 1 (Nap1), and Bendless (Ben). Each of these interactions was verified in cell culture or using antibodies generated specifically for the protein of int |
| 520 | |
▼a We have examined SMN protein interactions in the context of developing Drosophila melanogaster embryos, with follow-up studies in mouse, and human systems. When SMN is unable to self-oligomerize, the Slmb degron is highly accessible, and thus S |
| 590 | |
▼a School code: 0153. |
| 650 | 4 |
▼a Molecular biology. |
| 650 | 4 |
▼a Genetics. |
| 690 | |
▼a 0307 |
| 690 | |
▼a 0369 |
| 710 | 20 |
▼a The University of North Carolina at Chapel Hill.
▼b Genetics and Molecular Biology. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-10B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0153 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14996834
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자
▼b 관리자 |