가야대학교 분성도서관

상단 글로벌/추가 메뉴

회원 로그인

주메뉴

: • 전체검색; • 단행본; • 정기간행물; • 학위논문; • 비도서; • 특정번호 검색; • 기사색인; • 학습연구지원; • 지정도서

: • 전자자원통합검색; • 해외 WEB DB; • E-Book; • E-Learning; • 국내 WEB DB; • 인터넷검색

: • 대출현황조회/연장; • 예약현황조회/취소; • 희망도서; • 내서재; • 나의서평; • 나의태그; • 나의위젯; • RSS; • SDI; • 개인정보관리

: • 공지사항; • FAQ; • Q&A 일반·학술; • 신착/인기 도서; • 학위논문온라인제출; • 외부인 이용안내; • 설문조사

: • 도서관 소개; • 연혁; • 현황; • 이용안내; • 찾아오시는 길

자료검색

Home
상세정보

상세정보

검색결과 돌아가기

검색화면

부가기능

MARC보기

Networks of Splice Factor Regulation by Unproductive Splicing Coupled With NMD

상세 프로파일

상세정보
자료유형	E-Book
개인저자	Desai, Anna Maria.
단체저자명	University of California, Berkeley. Biological Science.
서명/저자사항	Networks of Splice Factor Regulation by Unproductive Splicing Coupled With NMD.
발행사항	[S.l.] : University of California, Berkeley., 2017
발행사항	Ann Arbor : ProQuest Dissertations & Theses, 2017
형태사항	80 p.
소장본 주기	School code: 0028.
ISBN	9780355832174
일반주기	Source: Dissertation Abstracts International, Volume: 79-08(E), Section: B. Adviser: Steven E. Brenner.
이용제한사항	This item is not available from ProQuest Dissertations & Theses.
요약	Virtually all multi-exon genes undergo alternative splicing (AS) to generate multiple protein isoforms. Alternative splicing is regulated by splicing factors, such as the serine/arginine rich (SR) protein family and the heterogeneous nuclear rib
요약	The NMD pathway has a role in preventing accumulation of erroneous transcripts with dominant negative phenotypes. During the pioneer round of translation, NMD recognizes mRNA transcripts with in-frame premature termination codons (PTCs) and degr
요약	Approximately 18% of expressed genes are reported to be natural targets of NMD, yet it still remains unclear why the human genome would express mRNAs that are immediately degraded by the NMD pathway. It is especially intriguing that splicing fac
요약	Regulation via alternative splicing coupled to NMD requires binding of a splicing factor to the regulated mRNA. CLIP-seq and related studies reveal that splicing factors bind abundantly to all transcripts of our selected 100 splicing factors. In
요약	Dr. Courtney French, Dr. Hu, and I combined experimental data and a model for NMD mechanism to identify targets of NMD. I inhibited NMD in HeLa and GM12878 cells via knockdown of UPF1 and SMG6, two core NMD factors, and by exposure to cyclohexim
일반주제명	Genetics. Biochemistry.
언어	영어
기본자료 저록	Dissertation Abstracts International79-08B(E). Dissertation Abstract International
대출바로가기	http://www.riss.kr/pdu/ddodLink.do?id=T14996763