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Networks of Splice Factor Regulation by Unproductive Splicing Coupled With NMD

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자료유형	E-Book
개인저자	Desai, Anna Maria.
단체저자명	University of California, Berkeley. Biological Science.
서명/저자사항	Networks of Splice Factor Regulation by Unproductive Splicing Coupled With NMD.
발행사항	[S.l.] : University of California, Berkeley., 2017
발행사항	Ann Arbor : ProQuest Dissertations & Theses, 2017
형태사항	80 p.
소장본 주기	School code: 0028.
ISBN	9780355832174
일반주기	Source: Dissertation Abstracts International, Volume: 79-08(E), Section: B. Adviser: Steven E. Brenner.
이용제한사항	This item is not available from ProQuest Dissertations & Theses.
요약	Virtually all multi-exon genes undergo alternative splicing (AS) to generate multiple protein isoforms. Alternative splicing is regulated by splicing factors, such as the serine/arginine rich (SR) protein family and the heterogeneous nuclear rib
요약	The NMD pathway has a role in preventing accumulation of erroneous transcripts with dominant negative phenotypes. During the pioneer round of translation, NMD recognizes mRNA transcripts with in-frame premature termination codons (PTCs) and degr
요약	Approximately 18% of expressed genes are reported to be natural targets of NMD, yet it still remains unclear why the human genome would express mRNAs that are immediately degraded by the NMD pathway. It is especially intriguing that splicing fac
요약	Regulation via alternative splicing coupled to NMD requires binding of a splicing factor to the regulated mRNA. CLIP-seq and related studies reveal that splicing factors bind abundantly to all transcripts of our selected 100 splicing factors. In
요약	Dr. Courtney French, Dr. Hu, and I combined experimental data and a model for NMD mechanism to identify targets of NMD. I inhibited NMD in HeLa and GM12878 cells via knockdown of UPF1 and SMG6, two core NMD factors, and by exposure to cyclohexim
일반주제명	Genetics. Biochemistry.
언어	영어
기본자료 저록	Dissertation Abstracts International79-08B(E). Dissertation Abstract International
대출바로가기	http://www.riss.kr/pdu/ddodLink.do?id=T14996763