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Understanding the Motility of Molecular Motors Using Theory and Simulations

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개인저자Goldtzvik, Yonathan.
단체저자명University of Maryland, College Park. Biophysics.
서명/저자사항Understanding the Motility of Molecular Motors Using Theory and Simulations.
발행사항[S.l.] : University of Maryland, College Park., 2017
발행사항Ann Arbor : ProQuest Dissertations & Theses, 2017
형태사항160 p.
소장본 주기School code: 0117.
ISBN9780355629057
일반주기 Source: Dissertation Abstracts International, Volume: 79-07(E), Section: B.
Adviser: Devarajan Thirumalai.
이용제한사항This item is not available from ProQuest Dissertations & Theses.
요약Molecular motors are indispensable machines that are in charge of transporting cargoes within living cells. Despite recent advances in the study of these molecules, there is much that we still do not understand regarding the underlying mechanism
요약Dynein is a large motor that transports cargo along microtubules towards their negative pole. Unlike other motors, such as conventional kinesin, the motility of dynein is highly stochastic. We developed a novel theoretical approach, which reprod
요약A less understood aspect of dynein is the complex set of allosteric transitions in response to ATP binding and hydrolysis, and microtubule binding. The resulting conformational transitions propel the motor forward to the minus end of the microtu
요약Kinesins are highly processive motor proteins that transport cargo along microtubules toward their positive poles. Experiments show that the kinesin motor domains propel the motor forward by passing each other in a hand-over-hand motion. However
일반주제명Biophysics.
Biology.
Molecular physics.
언어영어
기본자료 저록Dissertation Abstracts International79-07B(E).
Dissertation Abstract International
대출바로가기http://www.riss.kr/pdu/ddodLink.do?id=T14996697

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