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Arterial and Venous Impacts of Transdermally Administered Vasodilators on the Local Microvasculature

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개인저자Guo, George.
단체저자명Yale University. Yale School of Medicine.
서명/저자사항Arterial and Venous Impacts of Transdermally Administered Vasodilators on the Local Microvasculature.
발행사항[S.l.] : Yale University., 2017
발행사항Ann Arbor : ProQuest Dissertations & Theses, 2017
형태사항32 p.
소장본 주기School code: 0265.
ISBN9780438132092
일반주기 Source: Dissertation Abstracts International, Volume: 79-11(E), Section: B.
Adviser: David Silverman.
요약Microcirculatory function is an important component of cardiovascular pharmacology as related to cardiovascular dysfunction. We used photoplethysmography (PPG) to compare the microcirculatory effects of transdermal patches of rivastigmine (Exelo
요약Methods: With IRB approval, 10 healthy volunteers were monitored with PPG at the time each transdermal patch was applied and every 8 minutes afterwards for a total of 40 minutes. 1x1 cm portions of patches of rivastigmine, nicotine, and NTG were
요약Results: The max DeltaAC change for each drug were significantly different from that of its control while only the max DeltaDC of NTG was significantly greater than that of its control. Changes in the DeltaAC/DeltaDC ratio were found to be incon
요약Discussion: These results may provide some insight into the cardiovascular effects of the study agents used. NTG, a direct NO donor, caused significant increases in AC (arteriolar) and DC (venous) values. Acting at the pre/post ganglionic juncti
일반주제명Medicine.
언어영어
기본자료 저록Dissertation Abstracts International79-11B(E).
Dissertation Abstract International
대출바로가기http://www.riss.kr/pdu/ddodLink.do?id=T14996941

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