| LDR | | 00000nmm u2200205 4500 |
| 001 | | 000000329923 |
| 005 | | 20241016175737 |
| 008 | | 181129s2017 ||| | | | eng d |
| 020 | |
▼a 9780438132092 |
| 035 | |
▼a (MiAaPQ)AAI10747717 |
| 035 | |
▼a (MiAaPQ)medicine.yale:10640 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 049 | 1 |
▼f DP |
| 082 | 0 |
▼a 610 |
| 100 | 1 |
▼a Guo, George. |
| 245 | 10 |
▼a Arterial and Venous Impacts of Transdermally Administered Vasodilators on the Local Microvasculature. |
| 260 | |
▼a [S.l.] :
▼b Yale University.,
▼c 2017 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2017 |
| 300 | |
▼a 32 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-11(E), Section: B. |
| 500 | |
▼a Adviser: David Silverman. |
| 502 | 1 |
▼a Thesis (M.D.)--Yale University, 2017. |
| 520 | |
▼a Microcirculatory function is an important component of cardiovascular pharmacology as related to cardiovascular dysfunction. We used photoplethysmography (PPG) to compare the microcirculatory effects of transdermal patches of rivastigmine (Exelo |
| 520 | |
▼a Methods: With IRB approval, 10 healthy volunteers were monitored with PPG at the time each transdermal patch was applied and every 8 minutes afterwards for a total of 40 minutes. 1x1 cm portions of patches of rivastigmine, nicotine, and NTG were |
| 520 | |
▼a Results: The max DeltaAC change for each drug were significantly different from that of its control while only the max DeltaDC of NTG was significantly greater than that of its control. Changes in the DeltaAC/DeltaDC ratio were found to be incon |
| 520 | |
▼a Discussion: These results may provide some insight into the cardiovascular effects of the study agents used. NTG, a direct NO donor, caused significant increases in AC (arteriolar) and DC (venous) values. Acting at the pre/post ganglionic juncti |
| 590 | |
▼a School code: 0265. |
| 650 | 4 |
▼a Medicine. |
| 690 | |
▼a 0564 |
| 710 | 20 |
▼a Yale University.
▼b Yale School of Medicine. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-11B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0265 |
| 791 | |
▼a M.D. |
| 792 | |
▼a 2017 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14996941
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자
▼b 관리자 |