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Functional Regulation of Ion Channels in Dorsal Root Ganglion Neurons by Magi-1: Implications in Pain Signaling
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| 자료유형 | E-Book |
|---|---|
| 개인저자 | Pryce, Kerri D. |
| 단체저자명 | State University of New York at Buffalo. Pharmacology & Toxicology. |
| 서명/저자사항 | Functional Regulation of Ion Channels in Dorsal Root Ganglion Neurons by Magi-1: Implications in Pain Signaling. |
| 발행사항 | [S.l.] : State University of New York at Buffalo., 2018 |
| 발행사항 | Ann Arbor : ProQuest Dissertations & Theses, 2018 |
| 형태사항 | 134 p. |
| 소장본 주기 | School code: 0656. |
| ISBN | 9780438050013 |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B.
Adviser: Arindam Bhattacharjee. |
| 요약 | Persistent pain leads to alterations in ion channel expression in neurons along the pain-axis. Ion channels provide neurons with a mechanism to detect and respond to changes in their environment. Adaptive changes in ion channel expression are ma |
| 요약 | Nav1.8 channels are targeted for proteasome degradation through binding and subsequent ubiquitination by the Neural Precursor Cell Expressed, Developmentally Down-Regulated 4 (Nedd4) family of E-3 ubiquitin ligases, specifically Nedd4-2. Nedd4-2 |
| 요약 | In summary, this study provides evidence that Magi-1 is widely expressed in sensory neurons regulating ion channel trafficking, stability and plasma membrane expression. Furthermore, Magi-1 deficiency decreased pain responses through decreases i |
| 일반주제명 | Neurosciences. Pharmacology. Molecular biology. |
| 언어 | 영어 |
| 기본자료 저록 | Dissertation Abstracts International79-10B(E). Dissertation Abstract International |
| 대출바로가기 | http://www.riss.kr/pdu/ddodLink.do?id=T14998616 |
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| No. | 등록번호 | 청구기호 | 소장처 | 도서상태 | 반납예정일 | 예약 | 서비스 | 매체정보 |
|---|---|---|---|---|---|---|---|---|
| 1 | WE00024184 | 616 | 가야대학교// | 대출가능 |
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