| LDR | | 00000nmm u2200205 4500 |
| 001 | | 000000329857 |
| 005 | | 20241016155555 |
| 008 | | 181129s2018 ||| | | | eng d |
| 020 | |
▼a 9780438050013 |
| 035 | |
▼a (MiAaPQ)AAI10823948 |
| 035 | |
▼a (MiAaPQ)buffalo:15847 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 049 | 1 |
▼f DP |
| 082 | 0 |
▼a 616 |
| 100 | 1 |
▼a Pryce, Kerri D. |
| 245 | 10 |
▼a Functional Regulation of Ion Channels in Dorsal Root Ganglion Neurons by Magi-1: Implications in Pain Signaling. |
| 260 | |
▼a [S.l.] :
▼b State University of New York at Buffalo.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 134 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B. |
| 500 | |
▼a Adviser: Arindam Bhattacharjee. |
| 502 | 1 |
▼a Thesis (Ph.D.)--State University of New York at Buffalo, 2018. |
| 520 | |
▼a Persistent pain leads to alterations in ion channel expression in neurons along the pain-axis. Ion channels provide neurons with a mechanism to detect and respond to changes in their environment. Adaptive changes in ion channel expression are ma |
| 520 | |
▼a Nav1.8 channels are targeted for proteasome degradation through binding and subsequent ubiquitination by the Neural Precursor Cell Expressed, Developmentally Down-Regulated 4 (Nedd4) family of E-3 ubiquitin ligases, specifically Nedd4-2. Nedd4-2 |
| 520 | |
▼a In summary, this study provides evidence that Magi-1 is widely expressed in sensory neurons regulating ion channel trafficking, stability and plasma membrane expression. Furthermore, Magi-1 deficiency decreased pain responses through decreases i |
| 590 | |
▼a School code: 0656. |
| 650 | 4 |
▼a Neurosciences. |
| 650 | 4 |
▼a Pharmacology. |
| 650 | 4 |
▼a Molecular biology. |
| 690 | |
▼a 0317 |
| 690 | |
▼a 0419 |
| 690 | |
▼a 0307 |
| 710 | 20 |
▼a State University of New York at Buffalo.
▼b Pharmacology & Toxicology. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-10B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0656 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14998616
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자
▼b 관리자 |