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Development of PEG-peptide Scavenger Receptor Inhibitors for Non-viral Gene Delivery: An In-depth Analysis into the Properties which Influence Liver Uptake
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| 자료유형 | E-Book |
|---|---|
| 개인저자 | Allen, Rondine Joni-Ann. |
| 단체저자명 | The University of Iowa. Pharmacy. |
| 서명/저자사항 | Development of PEG-peptide Scavenger Receptor Inhibitors for Non-viral Gene Delivery: An In-depth Analysis into the Properties which Influence Liver Uptake. |
| 발행사항 | [S.l.] : The University of Iowa., 2018 |
| 발행사항 | Ann Arbor : ProQuest Dissertations & Theses, 2018 |
| 형태사항 | 190 p. |
| 소장본 주기 | School code: 0096. |
| ISBN | 9780438151697 |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
Adviser: Kevin Rice. |
| 요약 | Gene therapy can potentially treat a wide range of diseases ranging from inherited diseases to cancer. The successful use of nucleic acids to treat genetic diseases is limited by rapid capture and degradation of the nanoparticle by Kupffer cells |
| 요약 | PEG-peptides were found to inhibit scavenger receptors on the surface of Kupffer cells by forming albumin nanoparticles when intravenously dosed. This work explores the development of potent, low-molecular weight PEG-peptide inhibitors. In order |
| 요약 | Other properties including spatial distribution of leucine, hydrophobicity and peptide length were also explored to determine their effect on liver uptake. Hydrophobic peptides resulted in the formation of micelles which were inactive as scaveng |
| 일반주제명 | Pharmaceutical sciences. Pharmacology. |
| 언어 | 영어 |
| 기본자료 저록 | Dissertation Abstracts International79-12B(E). Dissertation Abstract International |
| 대출바로가기 | http://www.riss.kr/pdu/ddodLink.do?id=T14996891 |
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| No. | 등록번호 | 청구기호 | 소장처 | 도서상태 | 반납예정일 | 예약 | 서비스 | 매체정보 |
|---|---|---|---|---|---|---|---|---|
| 1 | WE00029025 | DP 615 | 가야대학교/전자책서버(컴퓨터서버)/ | 대출불가(별치) |
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