| LDR | | 00000nmm u2200205 4500 |
| 001 | | 000000334698 |
| 005 | | 20250205090638 |
| 008 | | 181129s2018 ||| | | | eng d |
| 020 | |
▼a 9780438151697 |
| 035 | |
▼a (MiAaPQ)AAI10746412 |
| 035 | |
▼a (MiAaPQ)uiowa:15480 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 049 | 1 |
▼f DP |
| 082 | 0 |
▼a 615 |
| 100 | 1 |
▼a Allen, Rondine Joni-Ann. |
| 245 | 10 |
▼a Development of PEG-peptide Scavenger Receptor Inhibitors for Non-viral Gene Delivery: An In-depth Analysis into the Properties which Influence Liver Uptake. |
| 260 | |
▼a [S.l.] :
▼b The University of Iowa.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 190 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B. |
| 500 | |
▼a Adviser: Kevin Rice. |
| 502 | 1 |
▼a Thesis (Ph.D.)--The University of Iowa, 2018. |
| 520 | |
▼a Gene therapy can potentially treat a wide range of diseases ranging from inherited diseases to cancer. The successful use of nucleic acids to treat genetic diseases is limited by rapid capture and degradation of the nanoparticle by Kupffer cells |
| 520 | |
▼a PEG-peptides were found to inhibit scavenger receptors on the surface of Kupffer cells by forming albumin nanoparticles when intravenously dosed. This work explores the development of potent, low-molecular weight PEG-peptide inhibitors. In order |
| 520 | |
▼a Other properties including spatial distribution of leucine, hydrophobicity and peptide length were also explored to determine their effect on liver uptake. Hydrophobic peptides resulted in the formation of micelles which were inactive as scaveng |
| 590 | |
▼a School code: 0096. |
| 650 | 4 |
▼a Pharmaceutical sciences. |
| 650 | 4 |
▼a Pharmacology. |
| 690 | |
▼a 0572 |
| 690 | |
▼a 0419 |
| 710 | 20 |
▼a The University of Iowa.
▼b Pharmacy. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-12B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0096 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14996891
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자
▼b 관리자 |