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Mechanistic Bases for the Adverse Interaction of Nicotine and Chronic Pain

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자료유형	E-Book
개인저자	Jareczek, Francis Josef.
단체저자명	The University of Iowa. Neuroscience.
서명/저자사항	Mechanistic Bases for the Adverse Interaction of Nicotine and Chronic Pain.
발행사항	[S.l.] : The University of Iowa., 2018
발행사항	Ann Arbor : ProQuest Dissertations & Theses, 2018
형태사항	189 p.
소장본 주기	School code: 0096.
ISBN	9780438151185
일반주기	Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B. Adviser: Donna L. Hammond.
요약	The adverse interaction between smoking and chronic pain has been known for decades. A variety of chronic pain conditions -- ranging from headache to low back pain to fibromyalgia -- markedly exacerbate smoking prevalence and intensity in packs
요약	A number of preclinical and clinical studies have documented that nicotinic acetylcholine receptor (nAChR) agonists, e.g., nicotine, have analgesic efficacy in the acute pain setting, such as that produced experimentally in the research laborato
요약	The complete Freund's adjuvant (CFA) model of chronic pain was employed to test the hypothesis that persistent inflammatory injury diminishes the antinociceptive efficacy of the selective and potent alpha4beta2 nAChR agonist epibatidine in key b
요약	Radioligand binding studies were conducted to test the most parsimonious hypothesis that a global reduction in alpha4beta2 nAChR number or binding affinity during persistent injury was in part responsible for the decreased efficacy of epibatidin
요약	To query functional changes with greater resolution, whole-cell patch clamp electrophysiology was employed to begin assessing the consequences of nAChR activation by nicotine at the level of the neuron. Initial studies performed in the locus coe
요약	Taken together, the present results demonstrate that persistent inflammatory injury produces adaptive changes in nicotinic signaling in the RVM such that the antinociceptive effects of epibatidine activation are abolished in a time-dependent man
일반주제명	Neurosciences.
언어	영어
기본자료 저록	Dissertation Abstracts International79-12B(E). Dissertation Abstract International
대출바로가기	http://www.riss.kr/pdu/ddodLink.do?id=T14996545