| LDR | | 02783nmm uu200433 4500 |
| 001 | | 000000334551 |
| 005 | | 20240805180530 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438151185 |
| 035 | |
▼a (MiAaPQ)AAI10247400 |
| 035 | |
▼a (MiAaPQ)uiowa:14848 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 616 |
| 100 | 1 |
▼a Jareczek, Francis Josef. |
| 245 | 10 |
▼a Mechanistic Bases for the Adverse Interaction of Nicotine and Chronic Pain. |
| 260 | |
▼a [S.l.] :
▼b The University of Iowa.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 189 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B. |
| 500 | |
▼a Adviser: Donna L. Hammond. |
| 502 | 1 |
▼a Thesis (Ph.D.)--The University of Iowa, 2018. |
| 520 | |
▼a The adverse interaction between smoking and chronic pain has been known for decades. A variety of chronic pain conditions -- ranging from headache to low back pain to fibromyalgia -- markedly exacerbate smoking prevalence and intensity in packs |
| 520 | |
▼a A number of preclinical and clinical studies have documented that nicotinic acetylcholine receptor (nAChR) agonists, e.g., nicotine, have analgesic efficacy in the acute pain setting, such as that produced experimentally in the research laborato |
| 520 | |
▼a The complete Freund's adjuvant (CFA) model of chronic pain was employed to test the hypothesis that persistent inflammatory injury diminishes the antinociceptive efficacy of the selective and potent alpha4beta2 nAChR agonist epibatidine in key b |
| 520 | |
▼a Radioligand binding studies were conducted to test the most parsimonious hypothesis that a global reduction in alpha4beta2 nAChR number or binding affinity during persistent injury was in part responsible for the decreased efficacy of epibatidin |
| 520 | |
▼a To query functional changes with greater resolution, whole-cell patch clamp electrophysiology was employed to begin assessing the consequences of nAChR activation by nicotine at the level of the neuron. Initial studies performed in the locus coe |
| 520 | |
▼a Taken together, the present results demonstrate that persistent inflammatory injury produces adaptive changes in nicotinic signaling in the RVM such that the antinociceptive effects of epibatidine activation are abolished in a time-dependent man |
| 590 | |
▼a School code: 0096. |
| 650 | 4 |
▼a Neurosciences. |
| 690 | |
▼a 0317 |
| 710 | 20 |
▼a The University of Iowa.
▼b Neuroscience. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-12B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0096 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14996545
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |