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Development and Validation of a Multinuclear Magnetic Resonance Spectroscopy Toolkit for Bioartificial Pancreas Assessment
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| 자료유형 | E-Book |
|---|---|
| 개인저자 | Einstein, Samuel Aaron. |
| 단체저자명 | University of Minnesota. Biophysical Sciences and Medical Physics. |
| 서명/저자사항 | Development and Validation of a Multinuclear Magnetic Resonance Spectroscopy Toolkit for Bioartificial Pancreas Assessment. |
| 발행사항 | [S.l.] : University of Minnesota., 2016 |
| 발행사항 | Ann Arbor : ProQuest Dissertations & Theses, 2016 |
| 형태사항 | 214 p. |
| 소장본 주기 | School code: 0130. |
| ISBN | 9780438350632 |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 80-01(E), Section: B.
Advisers: Michael Garwood |
| 요약 | Type 1 diabetes is a devastating disease with increasing incidence and prevalence. Insulin therapy, while life-saving, does not prevent severe complications that substantially increase both morbidity and mortality. Whole pancreas and pancreatic |
| 요약 | To enable and expedite TEG development, novel techniques to assess oxygen status (pO2) and viability were developed, validated, and applied. Hypoxia is currently the most significant obstruction preventing widespread utilization of TEGs, renderi |
| 요약 | This technique was applied to the murine model and demonstrated that TEGs implanted subcutaneously experience hypoxia unconducive to supporting islet viability and function. Therefore, a method for the delivery of supplemental oxygen (DSO) to in |
| 요약 | While providing crucial information, measuring pO2 does not necessarily correlate to islet viability, necessitating the development of additional techniques. Islet viability was first assessed by measuring pO 2 with 19F-MRS and calculating the o |
| 요약 | Finally, to facilitate in vivo viability assessment and increase measurement accuracy, oxygen-17 MRS was developed to directly measure and noninvasively quantify the OCR of TEGs. |
| 일반주제명 | Medical imaging. Surgery. Physics. |
| 언어 | 영어 |
| 기본자료 저록 | Dissertation Abstracts International80-01B(E). Dissertation Abstract International |
| 대출바로가기 | http://www.riss.kr/pdu/ddodLink.do?id=T14996513 |
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| No. | 등록번호 | 청구기호 | 소장처 | 도서상태 | 반납예정일 | 예약 | 서비스 | 매체정보 |
|---|---|---|---|---|---|---|---|---|
| 1 | WE00028846 | 616 | 가야대학교// | 대출가능 |
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