| LDR | | 02623nmm uu200469 4500 |
| 001 | | 000000334519 |
| 005 | | 20240805180451 |
| 008 | | 181129s2016 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438350632 |
| 035 | |
▼a (MiAaPQ)AAI10190091 |
| 035 | |
▼a (MiAaPQ)umn:17204 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 616 |
| 100 | 1 |
▼a Einstein, Samuel Aaron. |
| 245 | 10 |
▼a Development and Validation of a Multinuclear Magnetic Resonance Spectroscopy Toolkit for Bioartificial Pancreas Assessment. |
| 260 | |
▼a [S.l.] :
▼b University of Minnesota.,
▼c 2016 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2016 |
| 300 | |
▼a 214 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 80-01(E), Section: B. |
| 500 | |
▼a Advisers: Michael Garwood |
| 502 | 1 |
▼a Thesis (Ph.D.)--University of Minnesota, 2016. |
| 520 | |
▼a Type 1 diabetes is a devastating disease with increasing incidence and prevalence. Insulin therapy, while life-saving, does not prevent severe complications that substantially increase both morbidity and mortality. Whole pancreas and pancreatic |
| 520 | |
▼a To enable and expedite TEG development, novel techniques to assess oxygen status (pO2) and viability were developed, validated, and applied. Hypoxia is currently the most significant obstruction preventing widespread utilization of TEGs, renderi |
| 520 | |
▼a This technique was applied to the murine model and demonstrated that TEGs implanted subcutaneously experience hypoxia unconducive to supporting islet viability and function. Therefore, a method for the delivery of supplemental oxygen (DSO) to in |
| 520 | |
▼a While providing crucial information, measuring pO2 does not necessarily correlate to islet viability, necessitating the development of additional techniques. Islet viability was first assessed by measuring pO 2 with 19F-MRS and calculating the o |
| 520 | |
▼a Finally, to facilitate in vivo viability assessment and increase measurement accuracy, oxygen-17 MRS was developed to directly measure and noninvasively quantify the OCR of TEGs. |
| 590 | |
▼a School code: 0130. |
| 650 | 4 |
▼a Medical imaging. |
| 650 | 4 |
▼a Surgery. |
| 650 | 4 |
▼a Physics. |
| 690 | |
▼a 0574 |
| 690 | |
▼a 0576 |
| 690 | |
▼a 0605 |
| 710 | 20 |
▼a University of Minnesota.
▼b Biophysical Sciences and Medical Physics. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 80-01B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0130 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2016 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14996513
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |