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Characterization of Equine Metabolic Syndrome and Mapping of Candidate Genetic Loci

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개인저자Schultz, Nichol Elizabeth.
단체저자명University of Minnesota. Comparative and Molecular Biosciences.
서명/저자사항Characterization of Equine Metabolic Syndrome and Mapping of Candidate Genetic Loci.
발행사항[S.l.] : University of Minnesota., 2016
발행사항Ann Arbor : ProQuest Dissertations & Theses, 2016
형태사항375 p.
소장본 주기School code: 0130.
ISBN9780438030572
일반주기 Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B.
Advisers: James R. Mickelson
요약Equine metabolic syndrome (EMS) is a clustering of clinical signs associated with increased risk of laminitis, a potentially life-threatening condition of the foot. Similar to human metabolic syndrome (MetS), generalized and/or regional adiposit
요약Chapter 2 details the largest-ever epidemiological investigation of EMS in which 11 metabolic traits were measured in >600 horses and ponies from 166 farms. The use of multivariate, multilevel regression modeling allowed, for the first time, qua
요약Differences in the incretin response may also contribute to individual trait variation. The incretin response, defined as the difference in insulinemic responses between an oral and intravenous glucose challenge, is controlled by intestinal secr
요약In Chapter 4, an improved linear mixed model for mapping polygenic traits in a population with familial relationships similar to that in many equine GWAS was developed and validated. The model incorporates a Bayesian variable selection method to
일반주제명Genetics.
Animal diseases.
Statistics.
언어영어
기본자료 저록Dissertation Abstracts International79-10B(E).
Dissertation Abstract International
대출바로가기http://www.riss.kr/pdu/ddodLink.do?id=T14996465

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