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Tlr4-Activated Microglia Have Divergent Effects on Oligodendrocyte Lineage Cells

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개인저자Goldstein, Evan Zachary.
단체저자명The Ohio State University. Neuroscience.
서명/저자사항Tlr4-Activated Microglia Have Divergent Effects on Oligodendrocyte Lineage Cells.
발행사항[S.l.] : The Ohio State University., 2016
발행사항Ann Arbor : ProQuest Dissertations & Theses, 2016
형태사항217 p.
소장본 주기School code: 0168.
ISBN9780438309722
일반주기 Source: Dissertation Abstracts International, Volume: 80-01(E), Section: B.
Adviser: Dana McTigue.
요약Myelin accelerates action potential conduction velocity and provides essential metabolic support for axons. Unfortunately, myelin and myelinating cells are often vulnerable to injury or disease, resulting in myelin damage, which in turn can lead
요약Many factors produced by TLR4-activated microglia have no known effects on OL lineage cells. In chapter 3, colony stimulating factor 3 (CSF3) and interleukin 7 (IL-7) were identified as factors produced by TLR4-activated microglia that might con
요약In chapter 4, an innate TLR4-induced iron chelation response was harnessed to sequester iron in a model of intraspinal iron accumulation. Because excess iron induces progressive neuronal and OL death, we hypothesized that intraspinal TLR4 activa
일반주제명Medicine.
Molecular biology.
Biomedical engineering.
Immunology.
Neurosciences.
Biology.
언어영어
기본자료 저록Dissertation Abstracts International80-01B(E).
Dissertation Abstract International
대출바로가기http://www.riss.kr/pdu/ddodLink.do?id=T15001338

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