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Molecular Mechanisms of Flexibility in Nonhomologous End Joining
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| 자료유형 | E-Book |
|---|---|
| 개인저자 | Conlin, Michael Patrick. |
| 단체저자명 | The University of North Carolina at Chapel Hill. Genetics and Molecular Biology. |
| 서명/저자사항 | Molecular Mechanisms of Flexibility in Nonhomologous End Joining. |
| 발행사항 | [S.l.] : The University of North Carolina at Chapel Hill., 2018 |
| 발행사항 | Ann Arbor : ProQuest Dissertations & Theses, 2018 |
| 형태사항 | 115 p. |
| 소장본 주기 | School code: 0153. |
| ISBN | 9780438348271 |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 80-01(E), Section: B.
Adviser: Shawn Ahmed. |
| 요약 | DNA double strand breaks (DSBs) are highly toxic DNA lesions that play a critical role in human health and disease. The ability to repair these lesions is essential in all kingdoms of life, and in mammals is primarily attributed to the nonhomolo |
| 요약 | DNA Ligase IV (LIG4) is the only human DNA ligase that participates in NHEJ, and the only one that can efficiently ligate ends across gaps, or with terminal mispairs. We show by single-molecule analysis that terminal mispairs lead NHEJ complexes |
| 요약 | NHEJ employs two uniquely flexible polymerases to prepare ends for ligation: DNA polymerase micro (pol micro) and terminal deoxynucleotidyl transferase (TdT). These enzymes act on noncanonical substrates that other polymerases cannot engage. We |
| 일반주제명 | Molecular biology. Biochemistry. Genetics. |
| 언어 | 영어 |
| 기본자료 저록 | Dissertation Abstracts International80-01B(E). Dissertation Abstract International |
| 대출바로가기 | http://www.riss.kr/pdu/ddodLink.do?id=T14999018 |
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| No. | 등록번호 | 청구기호 | 소장처 | 도서상태 | 반납예정일 | 예약 | 서비스 | 매체정보 |
|---|---|---|---|---|---|---|---|---|
| 1 | WE00028324 | 574 | 가야대학교/전자책서버(컴퓨터서버)/ | 대출가능 |
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