| LDR | | 02175nmm uu200445 4500 |
| 001 | | 000000333997 |
| 005 | | 20240805174932 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438348271 |
| 035 | |
▼a (MiAaPQ)AAI10827376 |
| 035 | |
▼a (MiAaPQ)unc:17935 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 574 |
| 100 | 1 |
▼a Conlin, Michael Patrick. |
| 245 | 10 |
▼a Molecular Mechanisms of Flexibility in Nonhomologous End Joining. |
| 260 | |
▼a [S.l.] :
▼b The University of North Carolina at Chapel Hill.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 115 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 80-01(E), Section: B. |
| 500 | |
▼a Adviser: Shawn Ahmed. |
| 502 | 1 |
▼a Thesis (Ph.D.)--The University of North Carolina at Chapel Hill, 2018. |
| 520 | |
▼a DNA double strand breaks (DSBs) are highly toxic DNA lesions that play a critical role in human health and disease. The ability to repair these lesions is essential in all kingdoms of life, and in mammals is primarily attributed to the nonhomolo |
| 520 | |
▼a DNA Ligase IV (LIG4) is the only human DNA ligase that participates in NHEJ, and the only one that can efficiently ligate ends across gaps, or with terminal mispairs. We show by single-molecule analysis that terminal mispairs lead NHEJ complexes |
| 520 | |
▼a NHEJ employs two uniquely flexible polymerases to prepare ends for ligation: DNA polymerase micro (pol micro) and terminal deoxynucleotidyl transferase (TdT). These enzymes act on noncanonical substrates that other polymerases cannot engage. We |
| 590 | |
▼a School code: 0153. |
| 650 | 4 |
▼a Molecular biology. |
| 650 | 4 |
▼a Biochemistry. |
| 650 | 4 |
▼a Genetics. |
| 690 | |
▼a 0307 |
| 690 | |
▼a 0487 |
| 690 | |
▼a 0369 |
| 710 | 20 |
▼a The University of North Carolina at Chapel Hill.
▼b Genetics and Molecular Biology. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 80-01B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0153 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14999018
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |