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Mechanism for Nucleosome Organization Reconstituted Across a Eukaryotic Genome

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개인저자Wal, Megha.
단체저자명The Pennsylvania State University. Biochemistry, Microbiology and Molecular Biology.
서명/저자사항Mechanism for Nucleosome Organization Reconstituted Across a Eukaryotic Genome.
발행사항[S.l.] : The Pennsylvania State University., 2016
발행사항Ann Arbor : ProQuest Dissertations & Theses, 2016
형태사항200 p.
소장본 주기School code: 0176.
ISBN9780438136038
일반주기 Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
요약The eukaryotic genome is packaged into chromatin, which renders the DNA inaccessible to DNA-templated cellular processes. These include DNA replication, repair, recombination and transcription. Packaging of the genome into chromatin is achieved
요약While these studies have provided a basic framework to study the determinants of nucleosome positioning, a lot of questions still remain unanswered. We do not have a deep understanding about role of particular factors in different aspects of nuc
요약Specifically we show how nucleosome positioning is reconstituted in a step-wise manner using DNA, histones, chromatin remodelers and sequence-specific factors as minimal constituents. In stage 1, DNA sequence features determine NFR formation and
요약Taken together, the work in this thesis has provided advancement into the role of chromatin remodelers as major players in nucleosome organization. We provide some initial evidence for remodeler mechanisms in nucleosome restructuring and a minim
일반주제명Biochemistry.
Bioinformatics.
Molecular biology.
언어영어
기본자료 저록Dissertation Abstracts International79-12B(E).
Dissertation Abstract International
대출바로가기http://www.riss.kr/pdu/ddodLink.do?id=T15000735

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