| LDR | | 02348nmm uu200433 4500 |
| 001 | | 000000333868 |
| 005 | | 20240805174705 |
| 008 | | 181129s2016 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438136038 |
| 035 | |
▼a (MiAaPQ)AAI10903778 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 574 |
| 100 | 1 |
▼a Wal, Megha. |
| 245 | 10 |
▼a Mechanism for Nucleosome Organization Reconstituted Across a Eukaryotic Genome. |
| 260 | |
▼a [S.l.] :
▼b The Pennsylvania State University.,
▼c 2016 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2016 |
| 300 | |
▼a 200 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B. |
| 502 | 1 |
▼a Thesis (Ph.D.)--The Pennsylvania State University, 2016. |
| 520 | |
▼a The eukaryotic genome is packaged into chromatin, which renders the DNA inaccessible to DNA-templated cellular processes. These include DNA replication, repair, recombination and transcription. Packaging of the genome into chromatin is achieved |
| 520 | |
▼a While these studies have provided a basic framework to study the determinants of nucleosome positioning, a lot of questions still remain unanswered. We do not have a deep understanding about role of particular factors in different aspects of nuc |
| 520 | |
▼a Specifically we show how nucleosome positioning is reconstituted in a step-wise manner using DNA, histones, chromatin remodelers and sequence-specific factors as minimal constituents. In stage 1, DNA sequence features determine NFR formation and |
| 520 | |
▼a Taken together, the work in this thesis has provided advancement into the role of chromatin remodelers as major players in nucleosome organization. We provide some initial evidence for remodeler mechanisms in nucleosome restructuring and a minim |
| 590 | |
▼a School code: 0176. |
| 650 | 4 |
▼a Biochemistry. |
| 650 | 4 |
▼a Bioinformatics. |
| 650 | 4 |
▼a Molecular biology. |
| 690 | |
▼a 0487 |
| 690 | |
▼a 0715 |
| 690 | |
▼a 0307 |
| 710 | 20 |
▼a The Pennsylvania State University.
▼b Biochemistry, Microbiology and Molecular Biology. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-12B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0176 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2016 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T15000735
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |