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Mechanisms of Motivation in the Nucleus Accumbens

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자료유형	E-Book
개인저자	Cole, Shannon L.
단체저자명	University of Michigan. Psychology.
서명/저자사항	Mechanisms of Motivation in the Nucleus Accumbens.
발행사항	[S.l.] : University of Michigan., 2017
발행사항	Ann Arbor : ProQuest Dissertations & Theses, 2017
형태사항	231 p.
소장본 주기	School code: 0127.
ISBN	9780438126886
일반주기	Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B. Adviser: Kent C. Berridge.
요약	The nucleus accumbens (NAc) is a primary brain target of mesolimbic dopamine projections, and is well known to be important to motivation for rewards. Precisely how NAc neural systems generate motivation remains unclear. Here, I aimed to tease a
요약	First, I examined the role of the two main subpopulations of neurons in NAc (medium spiny neurons): NAc D1 neurons (i.e., containing D1-type dopamine receptors, and which form a 'direct pathway' for anatomical outputs to midbrain) versus D2 neur
요약	Next, I tested the relative roles of NAc neuronal hyperpolarization vs depolarization in generating intense motivation. A major hypothesis is NAc neuronal hyperpolarization (inhibition) generates motivation by releasing targets from constant sup
요약	Further, to test more directly whether NAc hyperpolarization is sufficient to enhance eating, I directly used inhibitory optogenetic laser techniques to hyperpolarize neurons without drugs. I found that in direct laser inhibition of NAc neurons
요약	In a final pilot dopamine experiment, I have examined how enhancement of dopamine release within the NAc can increase motivation for social exploration. I discovered that pairing laser activation of dopamine neurons to NA in TH Cre rats with enc
요약	Taken together, these studies illuminate key neural mechanisms through which the NAc produces reward motivation. These findings highlight how particular neural systems and neuronal states generate intense motivations for brain stimulation, food
일반주제명	Neurosciences.
언어	영어
기본자료 저록	Dissertation Abstracts International79-12B(E). Dissertation Abstract International
대출바로가기	http://www.riss.kr/pdu/ddodLink.do?id=T15000577