| LDR | | 00000nmm u2200205 4500 |
| 001 | | 000000333809 |
| 005 | | 20250121113342 |
| 008 | | 181129s2017 ||| | | | eng d |
| 020 | |
▼a 9780438126886 |
| 035 | |
▼a (MiAaPQ)AAI10903082 |
| 035 | |
▼a (MiAaPQ)umichrackham:001131 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 049 | 1 |
▼f DP |
| 082 | 0 |
▼a 616 |
| 100 | 1 |
▼a Cole, Shannon L. |
| 245 | 10 |
▼a Mechanisms of Motivation in the Nucleus Accumbens. |
| 260 | |
▼a [S.l.] :
▼b University of Michigan.,
▼c 2017 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2017 |
| 300 | |
▼a 231 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B. |
| 500 | |
▼a Adviser: Kent C. Berridge. |
| 502 | 1 |
▼a Thesis (Ph.D.)--University of Michigan, 2017. |
| 520 | |
▼a The nucleus accumbens (NAc) is a primary brain target of mesolimbic dopamine projections, and is well known to be important to motivation for rewards. Precisely how NAc neural systems generate motivation remains unclear. Here, I aimed to tease a |
| 520 | |
▼a First, I examined the role of the two main subpopulations of neurons in NAc (medium spiny neurons): NAc D1 neurons (i.e., containing D1-type dopamine receptors, and which form a 'direct pathway' for anatomical outputs to midbrain) versus D2 neur |
| 520 | |
▼a Next, I tested the relative roles of NAc neuronal hyperpolarization vs depolarization in generating intense motivation. A major hypothesis is NAc neuronal hyperpolarization (inhibition) generates motivation by releasing targets from constant sup |
| 520 | |
▼a Further, to test more directly whether NAc hyperpolarization is sufficient to enhance eating, I directly used inhibitory optogenetic laser techniques to hyperpolarize neurons without drugs. I found that in direct laser inhibition of NAc neurons |
| 520 | |
▼a In a final pilot dopamine experiment, I have examined how enhancement of dopamine release within the NAc can increase motivation for social exploration. I discovered that pairing laser activation of dopamine neurons to NA in TH Cre rats with enc |
| 520 | |
▼a Taken together, these studies illuminate key neural mechanisms through which the NAc produces reward motivation. These findings highlight how particular neural systems and neuronal states generate intense motivations for brain stimulation, food |
| 590 | |
▼a School code: 0127. |
| 650 | 4 |
▼a Neurosciences. |
| 690 | |
▼a 0317 |
| 710 | 20 |
▼a University of Michigan.
▼b Psychology. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-12B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0127 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2017 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T15000577
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자
▼b 관리자 |