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Retinoid X Receptor Activation by the Endocrine Disruptor Tributyltin Promotes Adipose Lineage Commitment and Perturbs Adipocyte Function

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개인저자Shoucri, Bassem Merit.
단체저자명University of California, Irvine. Biological Sciences.
서명/저자사항Retinoid X Receptor Activation by the Endocrine Disruptor Tributyltin Promotes Adipose Lineage Commitment and Perturbs Adipocyte Function.
발행사항[S.l.] : University of California, Irvine., 2018
발행사항Ann Arbor : ProQuest Dissertations & Theses, 2018
형태사항191 p.
소장본 주기School code: 0030.
ISBN9780438296176
일반주기 Source: Dissertation Abstracts International, Volume: 80-01(E), Section: B.
Includes supplementary digital materials.
Adviser: Bruce Blumberg.
요약The obesity epidemic has reached unsustainable proportions and threatens to bankrupt the American healthcare system. While physicians continue to prescribe diet and exercise as a panacea for obesity, mounting evidence shows that the majority of
요약Mounting evidence implicates early-life exposure to industrial chemicals---of which there are tens of thousands---as an overlooked contributor to the obesity epidemic. Of particular concern are a subset of at least 1,000 chemicals, termed endocr
요약Our lab identified and characterized the archetypal obesogen, tributyltin (TBT), which acts through two nuclear receptors, peroxisome proliferator-activated receptor gamma and retinoid X receptor (RXR), to promote the development of fat tissue.
요약The work described in this dissertation employs the in vitro MSC adipogenesis model to further explore the molecular mechanisms through which TBT alters the fate and function of developing stem cells. In Chapter 1, we investigate how TBT influ
일반주제명Developmental biology.
Endocrinology.
Molecular biology.
언어영어
기본자료 저록Dissertation Abstracts International80-01B(E).
Dissertation Abstract International
대출바로가기http://www.riss.kr/pdu/ddodLink.do?id=T14998339

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