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The Limiting DNA Replication Initiation Factors Sld2 and Sld3 Influence Replication Origin Efficiency Independent of Time of Origin Firing in Saccharomyces cerevisiae
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| 자료유형 | E-Book |
|---|---|
| 개인저자 | Lynch, Kelsey L. |
| 단체저자명 | University of Washington. Molecular and Cellular Biology. |
| 서명/저자사항 | The Limiting DNA Replication Initiation Factors Sld2 and Sld3 Influence Replication Origin Efficiency Independent of Time of Origin Firing in Saccharomyces cerevisiae. |
| 발행사항 | [S.l.] : University of Washington., 2018 |
| 발행사항 | Ann Arbor : ProQuest Dissertations & Theses, 2018 |
| 형태사항 | 150 p. |
| 소장본 주기 | School code: 0250. |
| ISBN | 9780438173859 |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
Adviser: Bonita J. Brewer. |
| 요약 | During S-phase in Saccharomyces cerevisiae, DNA replication is initiated from roughly 300 chromosomal origins that are regulated both by DNA sequence and by interacting protein factors. The limited abundance of a set of trans-acting initiation p |
| 요약 | I found that depleting cells of either initiation factor slows growth rate, increases S-phase duration, and causes viability defects, none of which are due to activation of the S phase checkpoint. Using genome-wide replication assays, I found th |
| 요약 | The viability defects induced by the depletion of these two limiting initiation factors suggested that the genome is destabilized by the systemic reduction of replication efficiency. Using pulsed-field gel electrophoresis to assay the integrity |
| 요약 | In summary, the cellular abundance of Sld2 and Sld3 contributes mostly to origin firing efficiency. In contrast to a recently proposed idea that origin firing time is a secondary consequence of origin efficiency, my work detailed in this dissert |
| 일반주제명 | Molecular biology. Genetics. Biology. |
| 언어 | 영어 |
| 기본자료 저록 | Dissertation Abstracts International79-12B(E). Dissertation Abstract International |
| 대출바로가기 | http://www.riss.kr/pdu/ddodLink.do?id=T14998175 |
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| No. | 등록번호 | 청구기호 | 소장처 | 도서상태 | 반납예정일 | 예약 | 서비스 | 매체정보 |
|---|---|---|---|---|---|---|---|---|
| 1 | WE00027593 | 574 | 가야대학교// | 대출가능 |
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