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Isolation of Circulating Tumor Cells and Clusters from Blood with Application in Drug Screening
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| 자료유형 | E-Book |
|---|---|
| 개인저자 | Shi, Wentao. |
| 단체저자명 | Lehigh University. Bioengineering. |
| 서명/저자사항 | Isolation of Circulating Tumor Cells and Clusters from Blood with Application in Drug Screening. |
| 발행사항 | [S.l.] : Lehigh University., 2018 |
| 발행사항 | Ann Arbor : ProQuest Dissertations & Theses, 2018 |
| 형태사항 | 152 p. |
| 소장본 주기 | School code: 0105. |
| ISBN | 9780438058354 |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B.
Adviser: Yaling Liu. |
| 요약 | Circulating tumor cell (CTC) plays a significant role to lead tumor become life-threatening. The appearance of CTC in the circulating system of tumor patients is deemed as the start of metastasis. To obtain CTC from blood is critical for vast bi |
| 요약 | Firstly, a wavy-herringbone (wavy-HB) structured microfluidic device is developed to effectively and selectively capture and release circulating tumor cells (CTCs) by using immunoaffinity and magnetic force. The device is designed to create pass |
| 요약 | Next, to isolate CTC clusters (CTCC), which has been shown to have higher invasiveness than CTC, a spiral channeled microfluidic device is introduced. By the centrifugal force created by spiral channels in microfluidic conditions, the device can |
| 요약 | To use the CTC and CTCC obtained from the first two techniques, a facile method for generation of tumor spheroids in large quantity with controllable size and high uniformity is presented. HCT116 cells are used as the model cell line. Individual |
| 요약 | Finally, to more closely mimicking the microenvironment of in vivo tumor, a bi-layer microfluidic device is presented to facilitate anti-tumor drug screening. The bi-layer microfluidic device consists of two PDMS pieces with channels and the two |
| 일반주제명 | Biomedical engineering. Bioengineering. |
| 언어 | 영어 |
| 기본자료 저록 | Dissertation Abstracts International79-10B(E). Dissertation Abstract International |
| 대출바로가기 | http://www.riss.kr/pdu/ddodLink.do?id=T14998082 |
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| No. | 등록번호 | 청구기호 | 소장처 | 도서상태 | 반납예정일 | 예약 | 서비스 | 매체정보 |
|---|---|---|---|---|---|---|---|---|
| 1 | WE00027504 | 610 | 가야대학교// | 대출가능 |
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