| LDR | | 02602nmm uu200445 4500 |
| 001 | | 000000333177 |
| 005 | | 20240805172337 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438058354 |
| 035 | |
▼a (MiAaPQ)AAI10813711 |
| 035 | |
▼a (MiAaPQ)lehigh:11923 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 610 |
| 100 | 1 |
▼a Shi, Wentao.
▼0 (orcid)0000-0002-0385-6109 |
| 245 | 10 |
▼a Isolation of Circulating Tumor Cells and Clusters from Blood with Application in Drug Screening. |
| 260 | |
▼a [S.l.] :
▼b Lehigh University.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 152 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B. |
| 500 | |
▼a Adviser: Yaling Liu. |
| 502 | 1 |
▼a Thesis (Ph.D.)--Lehigh University, 2018. |
| 520 | |
▼a Circulating tumor cell (CTC) plays a significant role to lead tumor become life-threatening. The appearance of CTC in the circulating system of tumor patients is deemed as the start of metastasis. To obtain CTC from blood is critical for vast bi |
| 520 | |
▼a Firstly, a wavy-herringbone (wavy-HB) structured microfluidic device is developed to effectively and selectively capture and release circulating tumor cells (CTCs) by using immunoaffinity and magnetic force. The device is designed to create pass |
| 520 | |
▼a Next, to isolate CTC clusters (CTCC), which has been shown to have higher invasiveness than CTC, a spiral channeled microfluidic device is introduced. By the centrifugal force created by spiral channels in microfluidic conditions, the device can |
| 520 | |
▼a To use the CTC and CTCC obtained from the first two techniques, a facile method for generation of tumor spheroids in large quantity with controllable size and high uniformity is presented. HCT116 cells are used as the model cell line. Individual |
| 520 | |
▼a Finally, to more closely mimicking the microenvironment of in vivo tumor, a bi-layer microfluidic device is presented to facilitate anti-tumor drug screening. The bi-layer microfluidic device consists of two PDMS pieces with channels and the two |
| 590 | |
▼a School code: 0105. |
| 650 | 4 |
▼a Biomedical engineering. |
| 650 | 4 |
▼a Bioengineering. |
| 690 | |
▼a 0541 |
| 690 | |
▼a 0202 |
| 710 | 20 |
▼a Lehigh University.
▼b Bioengineering. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-10B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0105 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14998082
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |