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Isolation and Characterization of HIV-1 Neutralizing Antibodies from Infants
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| 자료유형 | E-Book |
|---|---|
| 개인저자 | Simonich, Cassandra. |
| 단체저자명 | University of Washington. Molecular and Cellular Biology. |
| 서명/저자사항 | Isolation and Characterization of HIV-1 Neutralizing Antibodies from Infants. |
| 발행사항 | [S.l.] : University of Washington., 2018 |
| 발행사항 | Ann Arbor : ProQuest Dissertations & Theses, 2018 |
| 형태사항 | 198 p. |
| 소장본 주기 | School code: 0250. |
| ISBN | 9780438173668 |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
Adviser: Julie M. Overbaugh. |
| 요약 | Developing a protective HIV vaccine remains a key goal of prevention efforts. Broadly neutralizing antibodies (bnAbs) that recognize diverse circulating strains of HIV are thought to be an important component of a protective vaccine but elicitin |
| 요약 | First, we isolated nAbs contributing to a broad plasma response at one year post-infection from infant BF520. We observed that polyclonal nAbs with low SHM contribute to plasma neutralizing activity. Additionally, we isolated one infant-derived |
| 요약 | Next, we characterized the ontogeny of the infant-derived bnAb by reconstructing the naive progenitor and developmental intermediates. We observed that the naive antibody recognizes HIV Env, which contrasts with precursors of many adult bnAbs. T |
| 요약 | Finally, we isolated and characterized nAbs contributing to plasma breadth at two years post-infection from infant BG505. This infant is of particular interest to the HIV field because the Env of the transmitted virus from BG505 has been extensi |
| 요약 | These studies showed that infant antibodies have features distinct from adult antibodies, including several that may be amenable to better vaccine responses. This work represents the first isolation and characterization of a HIV-bnAb from an inf |
| 일반주제명 | Virology. Immunology. |
| 언어 | 영어 |
| 기본자료 저록 | Dissertation Abstracts International79-12B(E). Dissertation Abstract International |
| 대출바로가기 | http://www.riss.kr/pdu/ddodLink.do?id=T14997715 |
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| No. | 등록번호 | 청구기호 | 소장처 | 도서상태 | 반납예정일 | 예약 | 서비스 | 매체정보 |
|---|---|---|---|---|---|---|---|---|
| 1 | WE00027311 | 576.6 | 가야대학교/전자책서버(컴퓨터서버)/ | 대출가능 |
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