| LDR | | 02596nmm uu200445 4500 |
| 001 | | 000000332984 |
| 005 | | 20240805171952 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438173668 |
| 035 | |
▼a (MiAaPQ)AAI10792667 |
| 035 | |
▼a (MiAaPQ)washington:18432 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 576.6 |
| 100 | 1 |
▼a Simonich, Cassandra. |
| 245 | 10 |
▼a Isolation and Characterization of HIV-1 Neutralizing Antibodies from Infants. |
| 260 | |
▼a [S.l.] :
▼b University of Washington.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 198 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B. |
| 500 | |
▼a Adviser: Julie M. Overbaugh. |
| 502 | 1 |
▼a Thesis (Ph.D.)--University of Washington, 2018. |
| 520 | |
▼a Developing a protective HIV vaccine remains a key goal of prevention efforts. Broadly neutralizing antibodies (bnAbs) that recognize diverse circulating strains of HIV are thought to be an important component of a protective vaccine but elicitin |
| 520 | |
▼a First, we isolated nAbs contributing to a broad plasma response at one year post-infection from infant BF520. We observed that polyclonal nAbs with low SHM contribute to plasma neutralizing activity. Additionally, we isolated one infant-derived |
| 520 | |
▼a Next, we characterized the ontogeny of the infant-derived bnAb by reconstructing the naive progenitor and developmental intermediates. We observed that the naive antibody recognizes HIV Env, which contrasts with precursors of many adult bnAbs. T |
| 520 | |
▼a Finally, we isolated and characterized nAbs contributing to plasma breadth at two years post-infection from infant BG505. This infant is of particular interest to the HIV field because the Env of the transmitted virus from BG505 has been extensi |
| 520 | |
▼a These studies showed that infant antibodies have features distinct from adult antibodies, including several that may be amenable to better vaccine responses. This work represents the first isolation and characterization of a HIV-bnAb from an inf |
| 590 | |
▼a School code: 0250. |
| 650 | 4 |
▼a Virology. |
| 650 | 4 |
▼a Immunology. |
| 690 | |
▼a 0720 |
| 690 | |
▼a 0982 |
| 710 | 20 |
▼a University of Washington.
▼b Molecular and Cellular Biology. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-12B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0250 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14997715
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |