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Desmosomal Regulation of Gap Junction Dynamics and Cellular Contractility via Small GTPases: Implications for Cardiocutaneous Disease

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개인저자Kam, Chen Yuan.
단체저자명Northwestern University. Life Sciences.
서명/저자사항Desmosomal Regulation of Gap Junction Dynamics and Cellular Contractility via Small GTPases: Implications for Cardiocutaneous Disease.
발행사항[S.l.] : Northwestern University., 2018
발행사항Ann Arbor : ProQuest Dissertations & Theses, 2018
형태사항172 p.
소장본 주기School code: 0163.
ISBN9780438116153
일반주기 Source: Dissertation Abstracts International, Volume: 79-11(E), Section: B.
Adviser: Kathleen J. Green.
요약Desmoplakin (DP) is a component of desmosomes, critical adhesive complexes found in cardiac intercalated discs. DP is often mutated in arrhythmogenic cardiomyopathy (AC), an inherited disorder that is a frequent cause of sudden cardiac death. Th
요약Gap junctions, comprised of connexin (Cx) molecules are specialized intercellular channels that are indispensable in the myocardium where they coordinate the propagation of electrical signals between cardiomyocytes. Here, we elucidate a mechanis
요약Loss of DP was also found to perturb the junctional localization and activation of RhoA GTPase signaling in cardiomyocytes. The small GTPase RhoA plays a fundamental role in regulating actomyosin contractility via its various downstream effector
요약Finally, we investigated Plakophilin-2 (PKP2), a desmosome component that is critical for DP expression and localization in cardiac cells, and its role in promoting fibrotic signaling pathways in cardiac cells. Loss of PKP2 led to the activation
일반주제명Cellular biology.
Molecular biology.
언어영어
기본자료 저록Dissertation Abstracts International79-11B(E).
Dissertation Abstract International
대출바로가기http://www.riss.kr/pdu/ddodLink.do?id=T14997946

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