| LDR | | 02380nmm uu200433 4500 |
| 001 | | 000000332781 |
| 005 | | 20240805171556 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438116153 |
| 035 | |
▼a (MiAaPQ)AAI10810520 |
| 035 | |
▼a (MiAaPQ)northwestern:14092 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 574 |
| 100 | 1 |
▼a Kam, Chen Yuan. |
| 245 | 10 |
▼a Desmosomal Regulation of Gap Junction Dynamics and Cellular Contractility via Small GTPases: Implications for Cardiocutaneous Disease. |
| 260 | |
▼a [S.l.] :
▼b Northwestern University.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 172 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-11(E), Section: B. |
| 500 | |
▼a Adviser: Kathleen J. Green. |
| 502 | 1 |
▼a Thesis (Ph.D.)--Northwestern University, 2018. |
| 520 | |
▼a Desmoplakin (DP) is a component of desmosomes, critical adhesive complexes found in cardiac intercalated discs. DP is often mutated in arrhythmogenic cardiomyopathy (AC), an inherited disorder that is a frequent cause of sudden cardiac death. Th |
| 520 | |
▼a Gap junctions, comprised of connexin (Cx) molecules are specialized intercellular channels that are indispensable in the myocardium where they coordinate the propagation of electrical signals between cardiomyocytes. Here, we elucidate a mechanis |
| 520 | |
▼a Loss of DP was also found to perturb the junctional localization and activation of RhoA GTPase signaling in cardiomyocytes. The small GTPase RhoA plays a fundamental role in regulating actomyosin contractility via its various downstream effector |
| 520 | |
▼a Finally, we investigated Plakophilin-2 (PKP2), a desmosome component that is critical for DP expression and localization in cardiac cells, and its role in promoting fibrotic signaling pathways in cardiac cells. Loss of PKP2 led to the activation |
| 590 | |
▼a School code: 0163. |
| 650 | 4 |
▼a Cellular biology. |
| 650 | 4 |
▼a Molecular biology. |
| 690 | |
▼a 0379 |
| 690 | |
▼a 0307 |
| 710 | 20 |
▼a Northwestern University.
▼b Life Sciences. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-11B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0163 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14997946
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |