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Multivariate Analysis to Identify Potential Biomarkers for Prognosis and Treatment Resistance in Head and Neck Cancer Patients

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개인저자Wicker, Christina Ann.
단체저자명University of Kentucky. Toxicology and Cancer Biology.
서명/저자사항Multivariate Analysis to Identify Potential Biomarkers for Prognosis and Treatment Resistance in Head and Neck Cancer Patients.
발행사항[S.l.] : University of Kentucky., 2017
발행사항Ann Arbor : ProQuest Dissertations & Theses, 2017
형태사항229 p.
소장본 주기School code: 0102.
ISBN9780438239401
일반주기 Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
Adviser: Tadahide Izumi.
요약It is estimated that nearly 50,000 individuals in the United States will be diagnosed with head and neck cancer in 2017 (American Cancer Society www.cancer.org). Ninety percent of oral cancers are head and neck squamous cell carcinoma (HNSCC). M
요약Abnormal localization and overexpression of base excision repair protein and transcriptional regulator Apurinic/Apyrimidic endonuclease (APE1) has been associated with treatment resistance and poor prognosis. Therefore, we explored mechanisms fo
요약Because oxidative stress heavily influences APE1's expression and transcriptional regulatory activities, we examined genes involved in oxidative stress management, including SOD3 and NRF2. PPARGC1A, a NRF2 transcriptional co-activator, was also
요약To examine possible mechanisms for how APE1 regulates expression of tumor suppressors and antioxidants, digital image analysis of immunohistochemistry staining was used to identify alterations in protein expression. Nuclear and total cellular pr
요약Most importantly, potential prognostic biomarkers for use in early cancer development were identified. Identifying poor prognosis in early cancer development allows the possibility of improved treatment strategies, which could prevent invasive c
일반주제명Oncology.
Molecular biology.
Bioinformatics.
언어영어
기본자료 저록Dissertation Abstracts International79-12B(E).
Dissertation Abstract International
대출바로가기http://www.riss.kr/pdu/ddodLink.do?id=T15001225

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