| LDR | | 02657nmm uu200457 4500 |
| 001 | | 000000332160 |
| 005 | | 20240805170143 |
| 008 | | 181129s2017 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438239401 |
| 035 | |
▼a (MiAaPQ)AAI10954451 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 616.99 |
| 100 | 1 |
▼a Wicker, Christina Ann. |
| 245 | 10 |
▼a Multivariate Analysis to Identify Potential Biomarkers for Prognosis and Treatment Resistance in Head and Neck Cancer Patients. |
| 260 | |
▼a [S.l.] :
▼b University of Kentucky.,
▼c 2017 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2017 |
| 300 | |
▼a 229 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B. |
| 500 | |
▼a Adviser: Tadahide Izumi. |
| 502 | 1 |
▼a Thesis (Ph.D.)--University of Kentucky, 2017. |
| 520 | |
▼a It is estimated that nearly 50,000 individuals in the United States will be diagnosed with head and neck cancer in 2017 (American Cancer Society www.cancer.org). Ninety percent of oral cancers are head and neck squamous cell carcinoma (HNSCC). M |
| 520 | |
▼a Abnormal localization and overexpression of base excision repair protein and transcriptional regulator Apurinic/Apyrimidic endonuclease (APE1) has been associated with treatment resistance and poor prognosis. Therefore, we explored mechanisms fo |
| 520 | |
▼a Because oxidative stress heavily influences APE1's expression and transcriptional regulatory activities, we examined genes involved in oxidative stress management, including SOD3 and NRF2. PPARGC1A, a NRF2 transcriptional co-activator, was also |
| 520 | |
▼a To examine possible mechanisms for how APE1 regulates expression of tumor suppressors and antioxidants, digital image analysis of immunohistochemistry staining was used to identify alterations in protein expression. Nuclear and total cellular pr |
| 520 | |
▼a Most importantly, potential prognostic biomarkers for use in early cancer development were identified. Identifying poor prognosis in early cancer development allows the possibility of improved treatment strategies, which could prevent invasive c |
| 590 | |
▼a School code: 0102. |
| 650 | 4 |
▼a Oncology. |
| 650 | 4 |
▼a Molecular biology. |
| 650 | 4 |
▼a Bioinformatics. |
| 690 | |
▼a 0992 |
| 690 | |
▼a 0307 |
| 690 | |
▼a 0715 |
| 710 | 20 |
▼a University of Kentucky.
▼b Toxicology and Cancer Biology. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-12B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0102 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2017 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T15001225
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |