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Probing Composition and Binding of Viruses with Charge Detection Mass Spectrometry

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자료유형E-Book
개인저자Dunbar, Carmen A.
단체저자명Indiana University. Chemistry.
서명/저자사항Probing Composition and Binding of Viruses with Charge Detection Mass Spectrometry.
발행사항[S.l.] : Indiana University., 2018
발행사항Ann Arbor : ProQuest Dissertations & Theses, 2018
형태사항196 p.
소장본 주기School code: 0093.
ISBN9780438373334
일반주기 Source: Dissertation Abstracts International, Volume: 80-02(E), Section: B.
Adviser: Martin F. Jarrold.
요약Probing the composition of viruses can give insight into viral infectivity, antibody and virus binding affinity and protein stoichiometry. Unlike other commonly used characterization techniques, such as conventional mass spectrometry, and bioass
요약CDMS was used to characterize three different viral systems. First, Sindbis virus (SINV) from two host vectors was studied to determine the role of glycan and lipid composition on viral infectivity. CDMS was used to measure the mass intact SINV
요약Next Canine Parvovirus (CPV) was bound with fragment antibodies. The resulting capsid-antibody complex was measured using CDMS. Based on the mass shift between the unbound and bound CPV the total number of fragment antibodies bound was calculate
요약Lastly, the stoichiometry of ejection proteins in Bacteriophage P22 was characterized. The stoichiometry of ejection proteins was probed by monitoring the mass shift between P22 mutants with ejection proteins and P22 mutants with one or all ejec
일반주제명Analytical chemistry.
언어영어
기본자료 저록Dissertation Abstracts International80-02B(E).
Dissertation Abstract International
대출바로가기http://www.riss.kr/pdu/ddodLink.do?id=T15001004

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