| LDR | | 02255nmm uu200409 4500 |
| 001 | | 000000331582 |
| 005 | | 20240805164657 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438373334 |
| 035 | |
▼a (MiAaPQ)AAI10930859 |
| 035 | |
▼a (MiAaPQ)indiana:15420 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 543 |
| 100 | 1 |
▼a Dunbar, Carmen A. |
| 245 | 10 |
▼a Probing Composition and Binding of Viruses with Charge Detection Mass Spectrometry. |
| 260 | |
▼a [S.l.] :
▼b Indiana University.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 196 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 80-02(E), Section: B. |
| 500 | |
▼a Adviser: Martin F. Jarrold. |
| 502 | 1 |
▼a Thesis (Ph.D.)--Indiana University, 2018. |
| 520 | |
▼a Probing the composition of viruses can give insight into viral infectivity, antibody and virus binding affinity and protein stoichiometry. Unlike other commonly used characterization techniques, such as conventional mass spectrometry, and bioass |
| 520 | |
▼a CDMS was used to characterize three different viral systems. First, Sindbis virus (SINV) from two host vectors was studied to determine the role of glycan and lipid composition on viral infectivity. CDMS was used to measure the mass intact SINV |
| 520 | |
▼a Next Canine Parvovirus (CPV) was bound with fragment antibodies. The resulting capsid-antibody complex was measured using CDMS. Based on the mass shift between the unbound and bound CPV the total number of fragment antibodies bound was calculate |
| 520 | |
▼a Lastly, the stoichiometry of ejection proteins in Bacteriophage P22 was characterized. The stoichiometry of ejection proteins was probed by monitoring the mass shift between P22 mutants with ejection proteins and P22 mutants with one or all ejec |
| 590 | |
▼a School code: 0093. |
| 650 | 4 |
▼a Analytical chemistry. |
| 690 | |
▼a 0486 |
| 710 | 20 |
▼a Indiana University.
▼b Chemistry. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 80-02B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0093 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T15001004
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |