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Methods for Adapting Global Mass Spectrometry Based Metabolomics to the Clinical Environment

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자료유형E-Book
개인저자Wulff, Jacob Edward.
단체저자명The University of North Carolina at Chapel Hill. Biostatistics.
서명/저자사항Methods for Adapting Global Mass Spectrometry Based Metabolomics to the Clinical Environment.
발행사항[S.l.] : The University of North Carolina at Chapel Hill., 2018
발행사항Ann Arbor : ProQuest Dissertations & Theses, 2018
형태사항295 p.
소장본 주기School code: 0153.
ISBN9780438348721
일반주기 Source: Dissertation Abstracts International, Volume: 80-01(E), Section: B.
Includes supplementary digital materials.
Adviser: Lloyd J. Edwards.
요약Metabolomics is a maturing field with successful application to research areas such as biomarker discovery and mechanisms of disease. With the ability to profile hundreds or even thousands of biochemicals simultaneously, many of which are also u
요약The first paper explores basic properties of metabolites, specifically the statistical distribution of metabolite concentrations and correlation between them. In human sample sets covering three different sample material appropriate for clinical
요약In the second paper, application of the log transformation is used to account for missing values in estimating population parameters of a reference cohort. Missing values are largely attributed to the true level falling below the detection limit
요약The third paper addresses merging multiple global LC-MS metabolomic sets of the same biological sample type together. Typical normalization methods meant to account for sample to sample variation are presented and compared to alternative approac
일반주제명Biostatistics.
Analytical chemistry.
Biochemistry.
언어영어
기본자료 저록Dissertation Abstracts International80-01B(E).
Dissertation Abstract International
대출바로가기http://www.riss.kr/pdu/ddodLink.do?id=T14999656

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