| LDR | | 00000nmm u2200205 4500 |
| 001 | | 000000331171 |
| 005 | | 20241112174207 |
| 008 | | 181129s2018 ||| | | | eng d |
| 020 | |
▼a 9780438348721 |
| 035 | |
▼a (MiAaPQ)AAI10838903 |
| 035 | |
▼a (MiAaPQ)unc:17985 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 049 | 1 |
▼f DP |
| 082 | 0 |
▼a 574 |
| 100 | 1 |
▼a Wulff, Jacob Edward. |
| 245 | 10 |
▼a Methods for Adapting Global Mass Spectrometry Based Metabolomics to the Clinical Environment. |
| 260 | |
▼a [S.l.] :
▼b The University of North Carolina at Chapel Hill.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 295 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 80-01(E), Section: B. |
| 500 | |
▼a Includes supplementary digital materials. |
| 500 | |
▼a Adviser: Lloyd J. Edwards. |
| 502 | 1 |
▼a Thesis (Dr.P.H.)--The University of North Carolina at Chapel Hill, 2018. |
| 520 | |
▼a Metabolomics is a maturing field with successful application to research areas such as biomarker discovery and mechanisms of disease. With the ability to profile hundreds or even thousands of biochemicals simultaneously, many of which are also u |
| 520 | |
▼a The first paper explores basic properties of metabolites, specifically the statistical distribution of metabolite concentrations and correlation between them. In human sample sets covering three different sample material appropriate for clinical |
| 520 | |
▼a In the second paper, application of the log transformation is used to account for missing values in estimating population parameters of a reference cohort. Missing values are largely attributed to the true level falling below the detection limit |
| 520 | |
▼a The third paper addresses merging multiple global LC-MS metabolomic sets of the same biological sample type together. Typical normalization methods meant to account for sample to sample variation are presented and compared to alternative approac |
| 590 | |
▼a School code: 0153. |
| 650 | 4 |
▼a Biostatistics. |
| 650 | 4 |
▼a Analytical chemistry. |
| 650 | 4 |
▼a Biochemistry. |
| 690 | |
▼a 0308 |
| 690 | |
▼a 0486 |
| 690 | |
▼a 0487 |
| 710 | 20 |
▼a The University of North Carolina at Chapel Hill.
▼b Biostatistics. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 80-01B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0153 |
| 791 | |
▼a Dr.P.H. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14999656
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자
▼b 관리자 |