자료유형 | E-Book |
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개인저자 | Jacob, Noam. |
단체저자명 | University of California, Los Angeles. Molec, Cell, & Integ Physiology 0568. |
서명/저자사항 | Contributors to Intestinal Fibrosis in the TNFSF15/TL1A Pathway. |
발행사항 | [S.l.] : University of California, Los Angeles., 2018 |
발행사항 | Ann Arbor : ProQuest Dissertations & Theses, 2018 |
형태사항 | 111 p. |
소장본 주기 | School code: 0031. |
ISBN | 9780438146495 |
일반주기 |
Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
Adviser: Joseph R. Pisegna. |
요약 | Tumor necrosis factor-like cytokine 1A (TL1A, TNFSF15) is implicated in inflammatory bowel disease (IBD), modulating the location and severity of intestinal inflammation and fibrosis. TL1A expression is increased in inflamed gut mucosa and assoc |
요약 | We show that the gut microbiome is required for TL1A-mediated intestinal fibrosis and optimal fibroblast activation into myofibroblasts. Moreover, we provide evidence that the TL1A-mediated intestinal fibrotic phenotype requires cues provided by |
요약 | To evaluate for a selective role of direct TL1A-DR3 signaling on fibroblasts in fibrostenosing IBD, TL1A over-expressing naive T cells (Tl1a-Tg) were transferred into Rag-/- mice |
일반주제명 | Physiology. Biology. |
언어 | 영어 |
기본자료 저록 | Dissertation Abstracts International79-12B(E). Dissertation Abstract International |
대출바로가기 | http://www.riss.kr/pdu/ddodLink.do?id=T14999547 |