| LDR | | 02019nmm uu200421 4500 |
| 001 | | 000000331068 |
| 005 | | 20240805163347 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438146495 |
| 035 | |
▼a (MiAaPQ)AAI10837209 |
| 035 | |
▼a (MiAaPQ)ucla:17129 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 612 |
| 100 | 1 |
▼a Jacob, Noam. |
| 245 | 10 |
▼a Contributors to Intestinal Fibrosis in the TNFSF15/TL1A Pathway. |
| 260 | |
▼a [S.l.] :
▼b University of California, Los Angeles.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 111 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B. |
| 500 | |
▼a Adviser: Joseph R. Pisegna. |
| 502 | 1 |
▼a Thesis (Ph.D.)--University of California, Los Angeles, 2018. |
| 520 | |
▼a Tumor necrosis factor-like cytokine 1A (TL1A, TNFSF15) is implicated in inflammatory bowel disease (IBD), modulating the location and severity of intestinal inflammation and fibrosis. TL1A expression is increased in inflamed gut mucosa and assoc |
| 520 | |
▼a We show that the gut microbiome is required for TL1A-mediated intestinal fibrosis and optimal fibroblast activation into myofibroblasts. Moreover, we provide evidence that the TL1A-mediated intestinal fibrotic phenotype requires cues provided by |
| 520 | |
▼a To evaluate for a selective role of direct TL1A-DR3 signaling on fibroblasts in fibrostenosing IBD, TL1A over-expressing naive T cells (Tl1a-Tg) were transferred into Rag-/- mice |
| 590 | |
▼a School code: 0031. |
| 650 | 4 |
▼a Physiology. |
| 650 | 4 |
▼a Biology. |
| 690 | |
▼a 0719 |
| 690 | |
▼a 0306 |
| 710 | 20 |
▼a University of California, Los Angeles.
▼b Molec, Cell, & Integ Physiology 0568. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-12B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0031 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14999547
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |