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Derivatization Methods for Improved Metabolome Analysis by LC-MS/MS
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| 자료유형 | E-Book |
|---|---|
| 개인저자 | Malec, Paige A. |
| 단체저자명 | University of Michigan. Chemistry. |
| 서명/저자사항 | Derivatization Methods for Improved Metabolome Analysis by LC-MS/MS. |
| 발행사항 | [S.l.] : University of Michigan., 2018 |
| 발행사항 | Ann Arbor : ProQuest Dissertations & Theses, 2018 |
| 형태사항 | 163 p. |
| 소장본 주기 | School code: 0127. |
| ISBN | 9780438126268 |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
Adviser: Robert T. Kennedy. |
| 요약 | Metabolomics, the study and characterization of small molecule metabolites, faces challenges due to the size and diversity of the metabolome. No current instrumentation is capable of measuring the entire metabolome. Liquid chromatography with ma |
| 요약 | One way to overcome this limitation is through the use of chemical derivatization. Polar metabolites are labeled with a hydrophobic moiety, increasing retention and ionization efficiency in reversed phase chromatography, allowing for lower limit |
| 요약 | In this work, benzoyl chloride derivatization is expanded upon in both metabolome coverage and applicability. To allow benzoyl chloride derivatization of proteinaceous samples such as plasma or tissue, a sample preparation method was developed a |
| 요약 | With sample preparation optimized, we then aimed to expand metabolome coverage and subsequently developed a method for the analysis of 70 benzoylated neurochemicals. With nanomolar limits of detection and internal standards for each metabolite, |
| 요약 | Finally, we move away from benzoyl chloride and introduce a novel derivatization reagent, benzylamine. Benzylamine derivatization is complementary to benzoyl chloride, reacting with carboxylic acids, carbonyls, and phosphates. Moreover, the two |
| 일반주제명 | Neurosciences. |
| 언어 | 영어 |
| 기본자료 저록 | Dissertation Abstracts International79-12B(E). Dissertation Abstract International |
| 대출바로가기 | http://www.riss.kr/pdu/ddodLink.do?id=T15000527 |
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| No. | 등록번호 | 청구기호 | 소장처 | 도서상태 | 반납예정일 | 예약 | 서비스 | 매체정보 |
|---|---|---|---|---|---|---|---|---|
| 1 | WE00025169 | 616 | 가야대학교// | 대출가능 |
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